M0896

MPTP Hydrochloride

≥98% (AgNO3), powder, dopaminergic neurotoxin

• Synonim(y): MPTP HCl, Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride, MPTP hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₁₅N · HCl
• Numer CAS: 23007-85-4
• Masa cząsteczkowa: 209.72
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896578
• NACRES: NA.77
• Beilstein/REAXYS Number: 3707312
• MDL number: MFCD00012790
• Form: powder

Właściwości

• Nazwa produktu: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, powder
• form: powder
• Quality Segment: 200
• drug control: kontrollierte Droge in Deutschland
• color: white to off-white
• SMILES string: Cl[H].CN1CCC(=CC1)c2ccccc2
• InChI: 1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
• InChI key: KOWJANGMTAZWDT-UHFFFAOYSA-N

Opis

General description

MPTP shows its effects by causing inflammation, excitotoxicity, mitochondrial apoptosis, formation of inclusion bodies, and oxidative stress that leads to dopaminergic neuronal damage in the striatum and substantia nigra. In dopaminergic neurons, MPTP blocks the mitochondrial complex I which leads to mitochondrial dysfunction.

Application

MPTP has been used to study its effects on microglial innate immune memory. It has also been used to study the protective effects of phenylpropionamides in Pakinson’s diseased mice models.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride has been used to induce Parkinson′s disease (PD) in animal models:

• to study the effect of docosahexaenoic acid on the apelin distribution of the nervous system
• to study the behavioral impairments correlated to neurochemical deficits
• to study the effects of treadmill exercise on neuroprotection and neuroinflammation

Biochem/physiol Actions

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo and lead to oxidative stress. Thus MPP+ is generally acknowledged as the active metabolite of MPTP. MPTP is widely used in in vivo research studies as a model for Parkinsonism. A review describes the application of MPTP in studies related to programmed cell death in neurogenerative diseases.

Dopaminergic neurotoxin.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Disclaimer

Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301 + H311 + H331,H315,H319,H335,H370
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Ostrzeżenia: P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 1 - STOT SE 3
• Narządy docelowe: Nervous system, Respiratory system