SML4153

JPH203 hydrochloride

≥97% (HPLC)

• Synonim(y): (S)-2-Amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid dihydrochloride, JPH 203, dihydrochloride, JPH-203, dihydrochloride, KYT 0353, dihydrochloride, KYT-0353, dihydrochloride, KYT0353, dihydrochloride, Nanvuranlat, dihydrochloride, O-(5-Amino-2-phenylbenzoxazole-7-yl)methyl-3,5-dichloro-L-tyrosine dihydrochloride, O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride, SCHEMBL17360639, dihydrochloride
• Wzór empiryczny (zapis Hilla): C₂₃H₁₉Cl₂N₃O₄ · xHCl
• Numer CAS: 2417321-18-5
• Masa cząsteczkowa: 472.32 (free base basis)
• UNSPSC Code: 12352200
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

JPH203 (KYT-0353; Nanvuranlat) selectively inhibits L-type amino acid transporter LAT1-dependent L-leucine uptake and growth in HT-29 (IC50/GI50 = 0.06/4.1 μM) and human LAT1-expressing S2 murine renal proximal tubule cell cultures (IC50/GI50 = 0.14/16.4 μM), but not human LAT2-expressing S2 cells (IC50 >10, GI50 >1000 μM). When administered via intravenous injection, JPH203 effectively inhibits HT-29-derived tumor growth in mice in vivo (6.3-25 mg/kg via daily i.v. from d0 to d13).

Disclaimer

Hygroscopic, Store with desiccant

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable