SML4217

M324

≥98% (HPLC), powder, rucaparib metabolite

• Synonim(y): 4-(8-Fluoro-3,4,5,6-tetrahydro-6-oxo-1H-pyrrolo[4,3,2-ef][2]benzazepin-2-yl)benzoic acid, Rucaparib metabolite M324, rucaparib carboxy metabolite
• Wzór empiryczny (zapis Hilla): C₁₈H₁₃FN₂O₃
• Numer CAS: 1577998-89-0
• Masa cząsteczkowa: 324.31
• UNSPSC Code: 12352203
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Opis

Application

M324 may be used to study the inhibition properties of M324, potentially linking it to enhanced efficacy in cancer treatment.

Biochem/physiol Actions

M324 is a major (oxidative) metabolite of PARP1 inhibitor rucaparib which reaches plasma concentration levels comparable to those of the parent drug. But it retains weaker PARP inhibition activities (IC50 = 550 nM) than parent rucaparib (Ki = 1.4 and 0.17 nM PARP-1 and PARP-2 respectively). M324 has a differential kinase polypharmacology profile than parent drug. M324 inhibits PLK2 (IC50 = 591 nM) and GSK3A (IC50 = 579 nM) at clinical concentrations. Rucaparib and M324 exhibit synergistic effects in viability of prostate cancer cell lines. Also, M324 reduces α-synuclein accumulation in iPSC dopamine neurons in Parkinson’s disease models.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H315,H319
• Ostrzeżenia: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable