- A fluorescent probe for imaging p53-MDM2 protein-protein interaction.
A fluorescent probe for imaging p53-MDM2 protein-protein interaction.
Chemical biology & drug design (2014-09-18)
Zhenzhen Liu, Zhenyuan Miao, Jin Li, Kun Fang, Chunlin Zhuang, Lupei Du, Chunquan Sheng, Minyong Li
PMID25226874
ABSTRAKT
In this article, we describe a no-wash small-molecule fluorescent probe for detecting and imaging p53-MDM2 protein-protein interaction based on an environment-sensitive fluorescent turn-on mechanism. After extensive biological examination, this probe L1 exhibited practical activity and selectivity in vitro and in cellulo.
MATERIAŁY
Numer produktu
Marka
Opis produktu