- Synthesis of (-)-homogalanthamine from naltrexone.
Synthesis of (-)-homogalanthamine from naltrexone.
The Journal of organic chemistry (2011-03-09)
Naoshi Yamamoto, Hideaki Fujii, Satomi Imaide, Shigeto Hirayama, Toru Nemoto, Junji Inokoshi, Hiroshi Tomoda, Hiroshi Nagase
PMID21381712
ABSTRAKT
Acetylcholinesterase inhibitor (-)-homogalanthamine 3 was synthesized from μ opioid antagonist naltrexone (2) in 16% total yield. The synthesis features Grob fragmentation as a key reaction, which was especially accelerated in the presence of 15-crown-5.
MATERIAŁY