- Enantioselective total synthesis of the indole alkaloid 16-episilicine.
Enantioselective total synthesis of the indole alkaloid 16-episilicine.
Chemical communications (Cambridge, England) (2009-05-14)
Mercedes Amat, Begoña Checa, Núria Llor, Elies Molins, Joan Bosch
PMID19436915
ABSTRAKT
The first total synthesis of (-)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.
MATERIAŁY