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Pure red cell aplasia associated with recombinant erythropoietin: a case report and brief review of the literature.

The New Zealand medical journal (2013-12-10)
M Atif Mohd Slim, Riaz Shaik
ABSTRAKT

Pure red cell aplasia (PRCA) is a rare adverse effect of recombinant erythropoietin (rEPO). Affected patients rapidly become transfusion-dependent, with many requiring immunosuppressive therapy for remission. We report a confirmed case in an elderly female, possibly the first of its kind in New Zealand, who was started on rEPO for anaemia of chronic kidney disease. We also briefly review current literature on rEPO-associated PRCA.

MATERIAŁY
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Erythropoietin, BRP, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Erythropoietin human, EPO, recombinant, expressed in HEK 293 cells, suitable for cell culture