Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Journal of inorganic biochemistry (2011-11-22)

Joseph Lemire, Vasu D Appanna

PMID22099161

ABSTRAKT

Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.

MATERIAŁY

Numer produktu

Marka

Opis produktu

266574

Sigma-Aldrich

Aluminum, foil, thickness 0.45-0.55 mm, 99.999% trace metals basis

338788

Sigma-Aldrich

Aluminum, pellets, 3-12 mm, 99.99% trace metals basis

326852

Sigma-Aldrich

Aluminum, foil, thickness 0.25 mm, 99.999% trace metals basis

266957

Sigma-Aldrich

Aluminum, foil, thickness 1.0 mm, 99.999% trace metals basis

326860

Sigma-Aldrich

Aluminum, foil, thickness 0.13 mm, ≥99.99% trace metals basis

IRMM523A

Aluminum, IRMM^®, certified reference material, 0.1 mm foil

GF74590724

Aluminum, honeycomb, 600x600mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin glass fiber 0.5mm, 99.9%

GF26812043

Aluminum, foam, 150x150mm, thickness 3.2mm, bulk density 0.2g/cm³, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%

GF14206047

Aluminum, foam, 33x140mm, thickness 20mm, bulk density 0.2g/cm³, porosity 0.93, aluminum 6101 grade, 98.5%

GF46654375

Aluminum, honeycomb, 600x600mm, thickness 13.9mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%

GF70010222

Aluminum, honeycomb, 150x150mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm³, phenolic adhesive (resin), 99.5%

GF82602907

Aluminum, wire reel, 10m, diameter 1.0mm, as drawn, 99.5%

GF90308538

Aluminum, wire reel, 50m, diameter 0.125mm, as drawn, 99.99+%

GF50431193

Aluminum, wire reel, 1m, diameter 0.25mm, as drawn, 99.999%

GF22816830

Aluminum, wire reel, 50m, diameter 0.25mm, as drawn, 99.95+%

GF55106580

Aluminum, wire reel, 200m, diameter 1.0mm, as drawn, 99.95+%