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Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Journal of inorganic biochemistry (2011-11-22)

Joseph Lemire, Vasu D Appanna

ABSTRAKT

Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.

MATERIAŁY

Numer produktu

Marka

Opis produktu

Sigma-Aldrich

Aluminum, granular, <1 mm, 99.7% trace metals basis

Aluminum, IRMM^®, certified reference material, 1.0 mm foil

Aluminum, IRMM^®, certified reference material, 1.0 mm wire

Sigma-Aldrich

Aluminum, wire, diam. 1.0 mm, 99.999% trace metals basis

Sigma-Aldrich

Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

Sigma-Aldrich

Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis

Sigma-Aldrich

Aluminum, powder, ≥91% (complexometric)

Sigma-Aldrich

Aluminum, foil, thickness 8 μm, 99% trace metals basis

Aluminum, wire reel, 10m, diameter 0.025mm, as drawn, 99.0+%

Aluminum, wire reel, 50m, diameter 0.5mm, as drawn, 99.95+%

Aluminum, wire reel, 500m, diameter 0.7mm, as drawn, 99.5%

Aluminum, wire reel, 20m, diameter 1.0mm, as drawn, 99.5%

Sigma-Aldrich

Aluminum, ReagentPlus^®, beads, 5-15 mm, 99.9% trace metals basis

Sigma-Aldrich

Aluminum, ACS reagent, 99%, wire, wire diam. ~1.5 mm

Aluminum, wire reel, 50m, diameter 0.063mm, annealed, 99.99%

Aluminum, wire reel, 10m, diameter 0.5mm, as drawn, 99.999%

Aluminum, wire reel, 20m, diameter 0.125mm, as drawn, 99.99+%

Aluminum, wire reel, 500m, diameter 1.0mm, as drawn, 99.95+%

Aluminum, wire reel, 20m, diameter 0.02mm, hard, 99.99%

Aluminum, wire reel, 25m, diameter 0.30mm, as drawn, 99.5%

Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.99+%

Aluminum, wire reel, 5m, diameter 0.30mm, as drawn, 99.5%

Aluminum, wire reel, 50m, diameter 0.25mm, hard, 99.99+%

Aluminum, wire reel, 500m, diameter 0.25mm, as drawn, 99.5%

Aluminum, wire reel, 5m, diameter 0.25mm, as drawn, 99.999%

Aluminum, wire reel, 0.5m, diameter 1.0mm, as drawn, 99.999%

Aluminum, sphere, 100pcs, diameter 6.0mm, 99%

Aluminum, wire reel, 100m, diameter 0.05mm, as drawn, 99.99+%

Aluminum, rod, 200mm, diameter 12.0mm, as drawn, 99.999%

Aluminum, wire reel, 100m, diameter 0.25mm, as drawn, 99.5%