Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices.

Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices.

Nanomedicine (London, England) (2012-12-22)

Terje Sjöström, Alistair S Brydone, R M Dominic Meek, Matthew J Dalby, Bo Su, Laura E McNamara

ABSTRAKT

Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient's stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.

MATERIAŁY

Numer produktu

Marka

Opis produktu

266035

Sigma-Aldrich

Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis

369489

Sigma-Aldrich

Titanium, foil, thickness 2.0 mm, 99.7% trace metals basis

267902

Sigma-Aldrich

Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis

305812

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Titanium, ≤10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)

460400

Sigma-Aldrich

Titanium, wire, diam. 0.25 mm, 99.7% trace metals basis

348848

Sigma-Aldrich

Titanium, foil, thickness 0.025 mm, 99.98% trace metals basis

348791

Sigma-Aldrich

Titanium, foil, thickness 0.127 mm, 99.7% trace metals basis

IRMM531C

Titanium, IRMM^®, certified reference material, 0.5 mm wire

IRMM531B

Titanium, IRMM^®, certified reference material, 0.5 mm foil

GF91859967

Titanium, rod, 100mm, diameter 9.5mm, annealed, 99.99+%

GF06082286

Titanium, microfoil, disks, 10mm, thinness 1.0μm, specific density 429μg/cm², permanent mylar 3.5μm support, 99.6+%

GF72212813

Titanium, tube, 200mm, outside diameter 25.4mm, inside diameter 23.62mm, wall thickness 0.89mm, annealed, 99.6+%

GF12929744

Titanium, microfoil, disks, 25mm, thinness 0.25μm, specific density 112.6μg/cm², permanent mylar 3.5μm support, 99.6+%

GF64061760

Titanium, rod, 1000mm, diameter 16mm, annealed, 99.6+%

GF54883581

Titanium, rod, 1000mm, diameter 3.0mm, annealed, 99.6+%

GF16031843

Titanium, mesh, 100x100mm, nominal aperture 0.19mm, wire diameter 0.23mm, 60x60 wires/inch, open area 20%, twill weave

GF23916618

Titanium, microfoil, disks, 25mm, thinness 0.5μm, specific density 225.4μg/cm², permanent mylar 3.5μm support, 99.6+%

GF88742054

Titanium, tube, 200mm, outside diameter 4.25mm, inside diameter 3.75mm, wall thickness 0.25mm, annealed, 99.6+%

GF98611623

Titanium, rod, 200mm, diameter 8.0mm, as drawn, 99.99+%

GF24976525

Titanium, rod, 200mm, diameter 25mm, annealed, 99.6+%

GF84917188

Titanium, wire reel, 1m, diameter 0.25mm, as drawn, 99.99+%

GF90731505

Titanium, tube, 500mm, outside diameter 0.51mm, inside diameter 0.35mm, wall thickness 0.08mm, annealed, 99.6+%

GF97204990

Titanium, wire reel, 100m, diameter 0.25mm, annealed, 99.6+%

GF95731960

Titanium, tube, 500mm, outside diameter 3.0mm, inside diameter 1.5mm, wall thickness 0.75mm, annealed, 99.6+%

GF08595119

Titanium, wire reel, 100m, diameter 1.0mm, annealed, 99.6+%

GF52005596

Titanium, tube, 500mm, outside diameter 9.5mm, inside diameter 8.2mm, wall thickness 0.65mm, annealed, 99.6+%

GF46132534

Titanium, wire reel, 100m, diameter 0.25mm, as drawn, 99.6+%

GF16213553

Titanium, wire reel, 10m, diameter 0.125mm, annealed, 99.6+%

GF76266423

Titanium, wire reel, 0.5m, diameter 1.0mm, annealed, 99.6+%

GF16602768

Titanium, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%