[The toxicity of N,N-dimethylformamide (DMF)].

Industrial use of N, N-dimethylformamide (DMF) is increasing in recent years. The toxic properties of this substance are reviewed from the standpoint of industrial hygiene. Hepatotoxicity has been emphasized by many authors. Care should be taken against the skin absorption of DMF. N-methylformamide (MF) was identified as the major urinary metabolite of DMF. Measurements of MF in urine have been found effective as a means of biological monitoring of DMF exposure.