S6508

Sodium orthovanadate

≥90% (titration)

• Synonym(s): Trisodium vanadate
• Linear Formula: Na₃VO₄
• CAS Number: 13721-39-6
• Molecular Weight: 183.91
• EC Number: 237-287-9
• MDL number: MFCD00003511
• PubChem Substance ID: 24899708
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥90% (titration)
• form: crystalline powder
• reaction suitability: reagent type: catalyst; core: vanadium
• color: white to off-white
• mp: 850-866 °C (lit.)
• solubility: H₂O: soluble
• SMILES string: [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O
• InChI: 1S/3Na.4O.V/q3*+1;;3*-1;
• InChI key: IHIXIJGXTJIKRB-UHFFFAOYSA-N

Description

Application

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.²⁶ It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.²⁷

Biochem/physiol Actions

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.²⁴ In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.²⁵

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP₃)-induced Ca²⁺ release from endocrine cells and blocks IP₃ binding to its receptor in brain tissue.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332 - H315 - H319
• Precautionary Statements: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves