SRP0349

Flt3 active human

Name: Flt3 active human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Synonym(s):

CD135, FLK2, STK1, fms-related tyrosine kinase 3

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About This Item

CAS Number:

1688608-05-0

UNSPSC Code:

12352200

NACRES:

NA.32

Key Documents

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biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

54.2 kDa

packaging

pkg of 10 μg

technique(s)

activity assay: suitable
inhibition assay: suitable

NCBI accession no.

NM_004119

UniProt accession no.

P36888

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FLT3(2322)

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This Item	F6432	SRP0348	SRP0351
Sigma-Aldrich SRP0349 Flt3 active human	Sigma-Aldrich F6432 FLT3 (571-993), active, GST tagged human	Sigma-Aldrich SRP0348 Flt1 active human	Sigma-Aldrich SRP0351 PDGFRb active human
biological source human	biological source -	biological source human	biological source human
recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells
assay ≥80% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
technique(s) activity assay: suitable, inhibition assay: suitable	technique(s) -	technique(s) activity assay: suitable, inhibition assay: suitable	technique(s) activity assay: suitable, inhibition assay: suitable
form aqueous solution	form buffered aqueous glycerol solution	form aqueous solution	form aqueous solution
mol wt 54.2 kDa	mol wt ~73 kDa	mol wt 67.5 kDa	mol wt 62 kDa

General description

Human Flt3 (GenBank Accession No. NM_004119), amino acids 564-end with N-terminal His-tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Pictograms

GHS08

Signal Word

Danger

Hazard Statements

H360D

Precautionary Statements

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

4022520121

402251004

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Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235.

Connor P Hall et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 22(3), 621-632 (2015-06-18)

The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination with dexamethasone in acute lymphoblastic leukemia (ALL). The cytotoxic effects of BEZ235 and dexamethasone as single

Internal tandem duplications of the FLT3 gene are present in leukemia stem cells.

Mark Levis et al.

Blood, 106(2), 673-680 (2005-03-31)

Internal tandem duplication mutations of the FLT3 gene (FLT3/ITD mutations) are the most frequent molecular abnormality in acute myeloid leukemia (AML) and are associated with a poor overall survival. While the normal FLT3 receptor is expressed in early hematopoietic progenitor

Altered expression of CSF3R splice variants impacts signal response and is associated with SRSF2 mutations.

Amanda Lance et al.

Leukemia, 34(2), 369-379 (2019-08-30)

Three annotated CSF3R mRNA splice variants have been described. CSF3R-V1 is the wild-type receptor, while CSF3R-V4 is a truncated form increased in some patients with AML. CSF3R-V3 mRNA was identified in placenta more than 20 years ago, but remains largely

Over-expression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6.

Shinichiro Takahashi et al.

Leukemia research, 29(8), 893-899 (2005-06-28)

Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B

Fibroblast-Derived IL33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type 2 Immunity.

Ophir Shani et al.

Cancer research, 80(23), 5317-5329 (2020-10-08)

Lungs are one of the main sites of breast cancer metastasis. The metastatic microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer-associated fibroblasts (CAF) are prominent players in the microenvironment of breast cancer. However, their role in the

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