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High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy (2007-01-11)
Nicole Wolter, Anthony M Smith, Donald E Low, Keith P Klugman
ABSTRACT

A rare clinical isolate of Streptococcus pneumoniae, highly resistant to telithromycin, contained erm(B) with a truncated leader peptide and a mutant ribosomal protein L4. By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B), wild type or mutant, in combination with a (69)GTG(71)-to-TPS mutation in ribosomal protein L4.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Erythromycin, BioReagent, suitable for cell culture
Sigma-Aldrich
Tetracycline, 98.0-102.0% (HPLC)
Sigma-Aldrich
Erythromycin, potency: ≥850 μg per mg
Sigma-Aldrich
Erythromycin, meets USP testing specifications
Sigma-Aldrich
Erythromycin, tested according to Ph. Eur.