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Merck

400046

Hydroxyurea

≥98% (HPLC), solid, RNR inhibitor, Calbiochem

Synonym(s):

Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

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5 G

1 230,00 kr

1 230,00 kr

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About This Item

Empirical Formula (Hill Notation):
CH4N2O2
CAS Number:
127-07-1
Molecular Weight:
76.05
MDL number:
MFCD00007943
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Quality Level

100

description

Merck USA index - 14, 4848

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N(O)C(=O)N

InChI

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

InChI key

VSNHCAURESNICA-UHFFFAOYSA-N

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1 of 4

This Item
1332000H8627PHR2629
Hydroxyurea Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Sigma-Aldrich

400046

Hydroxyurea

Hydroxyurea United States Pharmacopeia (USP) Reference Standard

USP

1332000

Hydroxyurea

Hydroxyurea 98%, powder

Sigma-Aldrich

H8627

Hydroxyurea

Hydroxyurea Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2629

Hydroxyurea

assay

≥98% (HPLC)

assay

-

assay

98%

assay

-

form

solid

form

-

form

powder

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

-

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

water: 5 mg/mL

solubility

-

solubility

H2O: 50 mg/mL

solubility

-

General description

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

Other Notes

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H340,H361

Hazard Classifications

Muta. 1B - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Melissa Seman et al.
Cell reports, 42(11), 113428-113428 (2023-11-12)
H3K9 methylation (H3K9me) marks transcriptionally silent genomic regions called heterochromatin. HP1 proteins are required to establish and maintain heterochromatin. HP1 proteins bind to H3K9me, recruit factors that promote heterochromatin formation, and oligomerize to form phase-separated condensates. We do not understand
Xiaoju Hu et al.
NAR cancer, 4(3), zcac023-zcac023 (2022-07-29)
The histone methyltransferase KMT2C is among the most frequently mutated epigenetic modifier genes in cancer and plays an essential role in MRE11-dependent DNA replication fork restart. However, the effects of KMT2C deficiency on genomic instability during tumorigenesis are unclear. Analyzing
Kaisa Ikkala et al.
Scientific reports, 12(1), 161-161 (2022-01-09)
The cornea, transparent and outermost structure of camera-type eyes, is prone to environmental challenges, but has remarkable wound healing capabilities which enables to preserve vision. The manner in which cell plasticity impacts wound healing remains to be determined. In this
P Logan Schuck et al.
The Journal of biological chemistry, 297(3), 101026-101026 (2021-08-03)
Sister chromatid cohesion (SCC), the pairing of sister chromatids after DNA replication until mitosis, is established by loading of the cohesin complex on newly replicated chromatids. Cohesin must then be maintained until mitosis to prevent segregation defects and aneuploidy. However
Jesse D Cochran et al.
Scientific reports, 14(1), 1623-1623 (2024-01-19)
Asynchronously cycling cells pose a challenge to the accurate characterization of phase-specific gene expression. Current strategies, including RNAseq, survey the steady state gene expression across the cell cycle and are inherently limited by their inability to resolve dynamic gene regulatory
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