The stability of a 0.001% solution at 4°C has not been tested. A solution of 100 mg/ml in water is stable for 1 year at -80°C and for 1 month at -20°C. It is recommended to aliquot the stock solutions to avoid repeated freeze-thaw cycles.
K4894
Poloxamer 188
solid
Synonym(s):
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68
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Agency
USP/NF
meets USP testing specifications
form
solid
mol wt
8.400 g/mol
pH
5.0-7.5(2.5% solution)
application(s)
sample preservation
SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
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This Item | 1.37112 | P4894 | 16758 |
|---|---|---|---|
| form solid | form solid | form solid, waxy solid | form powder |
| application(s) sample preservation | application(s) liquid formulation | application(s) - | application(s) - |
| Quality Level 300 | Quality Level 500 | Quality Level 100 | Quality Level 100 |
| mol wt 8.400 g/mol | mol wt - | mol wt - | mol wt - |
| agency USP/NF | agency NF, Ph. Eur. | agency - | agency - |
| pH 5.0-7.5(2.5% solution) | pH 5-7.5 (20 °C, 10 g/L in H2O) | pH 5.0-7.5 | pH 5.0-7.5 |
General description
Poloxamer 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.[1]
Application
Poloxamer 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.[2]
Biochem/physiol Actions
Poloxamer 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2.[1]
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
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S Dhara et al.
Nature communications, 12(1), 3044-3044 (2021-05-26)
Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
Antibody humanization by molecular dynamics simulations?in-silico guided selection of critical backmutations
Christian Margretter
Journal of Molecular Recognition (2016)
Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
Denise Chroscinski
eLife (2015)
Martin Emanuele et al.
Drugs in R&D, 14(2), 73-83 (2014-04-12)
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer with hemorheologic, antithrombotic, anti-inflammatory, and cytoprotective properties. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis.
S Dhara et al.
Nature communications, 12(1), 3044-3044 (2021-05-26)
Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
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