The dispersant used is based on polyphosphoric acid, and approximately 0.25 wt% of hydroxyapatite is used.
702153
Hydroxyapatite
nanoparticles, dispersion, 10 wt. % in H2O, <200 nm particle size (BET)
Synonym(s):
Calcium hydroxide phosphate, Calcium hydroxylapatite, Calcium hydroxyphosphate, Nano hydroxyapatatite, Pentacalcium hydroxide triphosphate
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About This Item
Linear Formula:
[Ca5(OH)(PO4)3]x
CAS Number:
Molecular Weight:
502.31
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.23
Form:
dispersion
nanoparticles
nanoparticles
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form
dispersion
nanoparticles
contains
≤0.025 wt. % dispersant (non-metal based)
concentration
10 wt. % in H2O
surface area
14.3 m2/g , typical
particle size
<200 nm (BET)
pH
4-6
density
1.038 g/mL at 25 °C
SMILES string
[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O
InChI
1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10
InChI key
XYJRXVWERLGGKC-UHFFFAOYSA-D
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This Item | 677418 | 289396 | 693863 |
|---|---|---|---|
| form dispersion, nanoparticles | form nanopowder, solid | form powder, solid | form nanopowder, solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| pH 4-6 | pH - | pH - | pH - |
| density 1.038 g/mL at 25 °C | density - | density - | density - |
| contains ≤0.025 wt. % dispersant (non-metal based) | contains - | contains - | contains 5 wt. % silica as dopant |
| concentration 10 wt. % in H2O | concentration - | concentration - | concentration - |
General description
Hydroxyapatite(HAP) is an osteoconductive bioceramic material which has uniqueability to form direct bonds with living tissues. It can be easily prepared byvarious techniques such as sol-gel, hydrothermal, multiple emulsion, biomimeticdeposition, and electrodeposition.
Application
Hydroxyapatite can be used as:
- An implant material for bone substitute due to its chemical similarity to the inorganic component of bone and osteo inductive properties.
- A vehicle for gene and drug delivery because of its encapsulation capacity and affinity to several drugs and proteins.
- A pH responsive particulate emulsifier.
Features and Benefits
- Biocompatible
- Osteoconductive
- Stable under physiological conditions
- High mechanical strength
Legal Information
Product of Engi-Mat Co.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Martin P Reichhardt et al.
Life science alliance, 3(4) (2020-02-27)
The scavenger receptor cysteine-rich (SRCR) family of proteins comprises more than 20 membrane-associated and secreted molecules. Characterised by the presence of one or more copies of the ∼110 amino-acid SRCR domain, this class of proteins have widespread functions as antimicrobial
Thomas Lyon et al.
The Journal of bone and joint surgery. American volume, 95(23), 2088-2096 (2013-12-07)
Recombinant human bone morphogenetic protein-2 (rhBMP-2) applied on an absorbable collagen sponge improves open tibial fracture-healing as an adjunct to unreamed intramedullary nail fixation. We evaluated rhBMP-2 and a new, injectable calcium phosphate matrix (CPM) formulation in acute closed tibial
Tie Liu et al.
Bone, 56(1), 110-118 (2013-06-05)
As an alternative to an autologous bone graft, deproteinized bovine bone (DBB) is widely used in the clinical dentistry. Although DBB provides an osteoconductive scaffold, it is not capable of enhancing bone regeneration because it is not osteoinductive. In order
Liam M Grover et al.
Biomaterials, 34(28), 6631-6637 (2013-06-12)
Pyrophosphate ions are both inhibitors of HA formation and substrates for phosphatase enzymes. Unlike polyphosphates their hydrolysis results simultaneously in the complete loss of mineral formation inhibition and a localised elevation in orthophosphate ion concentration. Despite recent advances in our
Satyavrata Samavedi et al.
Acta biomaterialia, 9(9), 8037-8045 (2013-06-25)
Calcium phosphate ceramics (CPCs) have been widely used as biomaterials for the regeneration of bone tissue because of their ability to induce osteoblastic differentiation in progenitor cells. Despite the progress made towards fabricating CPCs possessing a range of surface features
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