This product is not assigned an expiration date. When stored appropriately at ?20°C, the material is quite stable. A warranty period of 1 year from the date of shipment applies to this item. Usage beyond that period would be up to the end user.
B2515
L-Buthionine-sulfoximine
synthetic (organic), ≥97% (TLC), γ-glutamylcysteine synthetase inhibitor, powder
Synonym(s):
L-BSO
Sign In to View Organizational & Contract Pricing.
Select a Size
500 MG
1 G
5 G
About This Item
Empirical Formula (Hill Notation):
C8H18N2O3S
CAS Number:
Molecular Weight:
222.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
2367136
Skip To
Product Name
L-Buthionine-sulfoximine, ≥97% (TLC)
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
SMILES string
CCCCS(=N)(=O)CC[C@H](N)C(O)=O
InChI key
KJQFBVYMGADDTQ-CVSPRKDYSA-N
biological source
synthetic (organic)
assay
≥97% (TLC)
form
powder
mp
224-226 °C
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... GCLC(2729), GCLM(2730)
Looking for similar products? Visit Product Comparison Guide
Related Categories
1 of 4
This Item | 19176 | B2640 | L9756 |
|---|---|---|---|
| biological source synthetic (organic) | biological source synthetic | biological source synthetic (organic) | biological source synthetic (organic) |
| assay ≥97% (TLC) | assay ≥99.0% (TLC) | assay ≥98% (TLC) | assay ≥99% (GC) |
| Gene Information human ... GCLC(2729), GCLM(2730) | Gene Information - | Gene Information - | Gene Information - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| form powder | form powder or crystals | form powder | form powder |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
Application
L-Buthionine-sulfoximine has been used:
- as a selective activator for the induction of ferroptosis in rat apoptotic cells[1]
- as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley[2]
- as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages[3]
Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
Biochem/physiol Actions
Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Triticale and barley microspore embryogenesis induction requires both reactive oxygen species generation and efficient system of antioxidative defence
Zur I, et al.
Plant Cell, Tissue and Organ Culture, 145(2), 347-366 (2021)
Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance.
Boris Epel et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 276, 31-36 (2017-01-17)
Thiol redox status is an important physiologic parameter that affects the success or failure of cancer treatment. Rapid scan electron paramagnetic resonance (RS EPR) is a novel technique that has shown higher signal-to-noise ratio than conventional continuous-wave EPR in in
Zeyu Cao et al.
Scientific reports, 7(1), 16278-16278 (2017-11-28)
Enterovirus 71 (EV71) is a key pathogen of hand, foot and mouth disease (HFMD) in children under 6 years of age. The antiviral potency of antioxidant isochlorogenic acid C (ICAC) extracted from foods was evaluated in cellular and animal models.
Tatjana Bosnjak et al.
Basic & clinical pharmacology & toxicology, 125(2), 89-99 (2019-03-28)
Proton pump inhibitors (PPIs) are prodrugs used in the treatment of peptic ulcer diseases. Once activated by acidic pH, the PPIs subsequently inhibit the secretion of gastric acid by covalently forming disulphide bonds with the SH groups of the parietal
S Busker et al.
Science advances, 6(12), eaax7945-eaax7945 (2020-03-29)
Because of its key role in cancer development and progression, STAT3 has become an attractive target for developing new cancer therapeutics. While several STAT3 inhibitors have progressed to advanced stages of development, their underlying biology and mechanisms of action are
-
Hi, I've kept this product (powder) in the fridge for a longer period (Approx. 1 year). Is it still okey to use or should I consider buying another one and keep it in the freezer?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service