M6324

MART-1 (27-35), Human

Name: MART-1 (27-35), Human
Brand: SIGMA

Synonym(s):

Antigen LB39-AA (27-35) (human), Antigen SK29-AA (27-35) (human), Melan-A Protein (27-35) (human), Melanoma Antigen Recognized By T-Cells 1 (27-35) (human)

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

Key Documents

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form

lyophilized powder

Quality Level

200

color

white

solubility

water, double-distilled: soluble

storage temp.

−20°C

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This Item	M6449	SAB4500949	ZRB1963
Sigma-Aldrich M6324 MART-1 (27-35), Human	Sigma-Aldrich M6449 MART-1 (26-35), Human	Sigma-Aldrich SAB4500949 Anti-MART-1 antibody produced in rabbit	Sigma-Aldrich ZRB1963 Anti-MART-1 Antibody, clone 1H17 ZooMAb^® Rabbit Monoclonal
form lyophilized powder	form lyophilized powder	form buffered aqueous solution	form lyophilized
solubility water, double-distilled: soluble	solubility water, double-distilled: soluble	solubility -	solubility -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
color white	color white	color -	color -

Amino Acid Sequence

Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val

General description

Melanoma-associated antigen recognized by T cells-1 (MART-1), also known as Melan-A, is encoded by the gene mapped to human chromosome 9p24.1.[1] The encoded protein is a hydrophobic transmembrane protein.[2] MART-1 is mainly expressed in skin and retinae melanocytes.[2]

The peptide represents amino acids 27-35 of MART-1 protein that is the melanoma antigen recognized by T cells. This peptide mimics the natural epitope that is presented by T cells in humans with reactivity to melanoma cells.

Biochem/physiol Actions

Melanoma-associated antigen recognized by T cells-1 (MART-1) is essential for the functioning of glycoprotein-100 (gp100). Overexpression of the gene has been observed in cutaneous melanoma (CM).[2] In addition, deletion of Mart-1 gene leads to parotid metastatic melanoma.[1]

Physical form

Lyophilized from 0.1% aqueous TFA

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis

Guo R, et al.

International Journal of Clinical and Experimental Pathology, 7(1), 468-468 (2014)

Human macrophages and dendritic cells can equally present MART-1 antigen to CD8(+) T cells after phagocytosis of gamma-irradiated melanoma cells.

María Marcela Barrio et al.

PloS one, 7(7), e40311-e40311 (2012-07-07)

Dendritic cells (DC) can achieve cross-presentation of naturally-occurring tumor-associated antigens after phagocytosis and processing of dying tumor cells. They have been used in different clinical settings to vaccinate cancer patients. We have previously used gamma-irradiated MART-1 expressing melanoma cells as

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