T8700
Anti-Tyrosine Hydroxylase antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution, sufficient for 10 blots
Synonym(s):
Rabbit Anti-TYH
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
usage
sufficient for 10 blots
species reactivity
mammals
technique(s)
immunohistochemistry (frozen sections): 1:1,000
indirect immunofluorescence: 1:1,000
western blot: 1:1,000 using rat brain lysates of PC-12 cells stimulated by okadaic acid
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
1 of 4
This Item | T2928 | SAB4502966 | SAB4503789 |
|---|---|---|---|
| biological source rabbit | biological source mouse | biological source rabbit | biological source rabbit |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| antibody form affinity isolated antibody | antibody form ascites fluid | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| Gene Information human ... TH(7054) | Gene Information human ... TH(7054) | Gene Information human ... TH(7054) | Gene Information human ... TH(7054) |
| shipped in wet ice | shipped in dry ice | shipped in wet ice | shipped in wet ice |
General description
Tyrosine hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15. TH is a tetramer of four identical subunits, which is characterized with a regulatory, catalytic, and tetramerization domains. The enzyme utilizes tyrosine, tetrahydrobiopterin (BH4) and O2 as cosubstrates, and Fe2+ as a cofactor.
Tyrosine hydroxylase (TH) is involved in the conversion of phenylalanine to dopamine. It catalyzes the initial, rate-limiting step of the catecholamine biosynthetic pathway.
Immunogen
SDS-denatured rat tyrosine hydroxylase purified from pheochromocytoma.
Application
Anti-tyrosine hydroxylase antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.[1]
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Tyrosine hydroxylase (TH) catalyzes the first rate limiting step in the biosynthesis of catecholamine neurotransmitter i.e. the conversion of L-tyrosine to L-dopa. Inhibition of TH by L-phenylalanine, might play a crucial role in phenylketonuria and block the synthesis of norepinephrine. Activity of TH can be regulated by phosphorylation. Decreased expression of TH is associated with various neuropsychiatric diseases such as schizophrenia and Parkinson′s disease (PD).
Physical form
Solution in 100 μL in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Maheep Bhatnagar et al.
PloS one, 12(5), e0177254-e0177254 (2017-05-17)
Parkinson's disease remains as one of the most common debilitating neurodegenerative disorders. With the hopes of finding agents that can cure or reduce the pace of progression of the disease, we studied two traditional medicinal plants: Centella asiatica and Withania
Jorge Mendoza et al.
Journal of neurochemistry, 112(6), 1489-1499 (2010-01-14)
Under special restricted feeding conditions the mammalian circadian clock, contained in the hypothalamic suprachiasmatic nucleus (SCN), can be entrained by food. During food restriction, hungry animals are very motivated to obtain food. This motivational state could be a key component
Yanqin Wang et al.
PPAR research, 2017, 4089214-4089214 (2017-03-31)
The aim of the present study was to gain insight into the neuroprotection effects and mechanism of thiazolidinedione pioglitazone in both in vitro and in vivo MPP+/MPTP induced PD models. In vivo experimental results showed that oral treatment of pioglitazone
Rihua Wang et al.
Cell death & disease, 9(3), 352-352 (2018-03-04)
Astrocytic JWA exerts neuroprotective roles by alleviating oxidative stress and inhibiting inflammation. However, the molecular mechanisms of how astrocytic JWA is involved in dopaminergic neurodegeneration in Parkinson's disease (PD) remain largely unknown. In this study, we found that astrocyte-specific JWA
Fanhua Meng et al.
Oncology letters, 13(1), 296-300 (2017-01-27)
The incidence rate of Parkinson's disease (PD) is ≤2% in Chinese individuals >65 years old, accounting for 40% of the global total of PD patients. The pathogenesis of PD is not yet clear, and oxidative stress-induced mitochondrial dysfunction is considered
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