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Merck

CRK

v-crk avian sarcoma virus CT10 oncogene homolog

Synonyms:
CRKII, p38
สายพันธุ์:
UniProtKB ID:
รหัสยีน:
  • Human(1398) Summary: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
  • Mouse(12928) v-crk sarcoma virus CT10 oncogene homolog (avian)
  • Rat(54245) v-crk avian sarcoma virus CT10 oncogene homolog
  • Thale Cress(824217) CDPK-related kinase
  • Thale Cress(828087) actin related protein 2/3 complex, subunit 5
  • fruit fly(43775) CG1587 gene product from transcript CG1587-RD
  • fruit fly(248187) crooked setae
  • Zebrafish(445234) v-crk sarcoma virus CT10 oncogene homolog (avian)
  • chicken(417553) v-crk sarcoma virus CT10 oncogene homolog
  • dog(100684309) v-crk sarcoma virus CT10 oncogene homolog (avian)
  • domestic cat(101086100) v-crk sarcoma virus CT10 oncogene homolog (avian)
  • cow(512841) v-crk sarcoma virus CT10 oncogene homolog (avian)
  • sheep(101115380) v-crk sarcoma virus CT10 oncogene homolog (avian)
  • domestic guinea pig(100718486) v-crk sarcoma virus CT10 oncogene homolog (avian)
  • naked mole-rat(101717585) v-crk sarcoma virus CT10 oncogene homolog (avian)

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