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Merck

K1884

S-(+)-Ketamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H16ClNO · HCl
CAS Number:
33643-47-9
Molecular Weight:
274.19
NACRES:
NA.77
PubChem Substance ID:
329817128
UNSPSC Code:
12352116
MDL number:
MFCD00274163

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InChI

1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H/t13-;/m0./s1

SMILES string

Cl.CN[C@@]1(CCCCC1=O)c2ccccc2Cl

InChI key

VCMGMSHEPQENPE-ZOWNYOTGSA-N

form

powder

drug control

USDEA Schedule III; stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)

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This Item
K2753K113K4138
S-(+)-Ketamine hydrochloride

Sigma-Aldrich

K1884

S-(+)-Ketamine hydrochloride

(±)-Ketamine hydrochloride solid

Sigma-Aldrich

K2753

(±)-Ketamine hydrochloride

Ketamine hydrochloride/xylazine hydrochloride solution

Sigma-Aldrich

K113

Ketamine hydrochloride/xylazine hydrochloride solution

Ketamine hydrochloride/xylazine hydrochloride solution

Sigma-Aldrich

K4138

Ketamine hydrochloride/xylazine hydrochloride solution

form

powder

form

solid

form

solution

form

aqueous solution

drug control

USDEA Schedule III; stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)

drug control

USDEA Schedule III; stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)

drug control

USDEA Schedule III; stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)

drug control

USDEA Schedule III; stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)

Gene Information

-

Gene Information

-

Biochem/physiol Actions

Selective NMDA glutamate receptor antagonist.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
SLBR7730V
SLBR7729V
SLBR7728V
SLBQ5773V
SLBL4202V

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Martin Chopra et al.
PloS one, 8(12), e81320-e81320 (2013-12-19)
To promote cancer research and to develop innovative therapies, refined pre-clinical mouse tumor models that mimic the actual disease in humans are of dire need. A number of neoplasms along the B cell lineage are commonly initiated by a translocation
M Nishimura et al.
Neuroscience letters, 274(2), 131-134 (1999-12-20)
Ketamine is usually administered as a racemate, which is composed of the two isomers, S(+)-and R(-)-ketamine. Recently, we have shown that racemic ketamine at clinical relevant concentrations specifically inhibits the transporter proteins for norepinephrine, dopamine and serotonin heterologously expressed in
Adam L Halberstadt et al.
Psychopharmacology, 233(7), 1215-1225 (2016-01-14)
Methoxetamine (MXE) is a ketamine analog sold online that has been subject to widespread abuse for its dissociative and hallucinogenic effects. Previous studies have shown that MXE has high affinity for the phencyclidine (PCP) binding site located within the channel
T Kawasaki et al.
Anesthesia and analgesia, 89(3), 665-669 (1999-09-04)
The production of proinflammatory cytokines, such as tumor necrosis factor (TNF) a, interleukin (IL)-6, and IL-8, increases in patients with sepsis; marked production causes organ failure and septic shock. We previously reported that ketamine suppressed lipopolysaccharide (LPS)-induced TNF-alpha production in
Kallol Bera et al.
Frontiers in cellular neuroscience, 13, 499-499 (2019-12-05)
The target for the "rapid" (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants. To describe a drug's target, one must first understand the compartments entered by the drug, at all levels-the
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