MilliporeSigma

ACHE

acetylcholinesterase

Synonyms:
ACEE, ARACHE, N-ACHE, YT
Species:
UniProtKB ID:
Gene ID:
  • Human(43) Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
  • Mouse(11423) acetylcholinesterase
  • Rat(83817) acetylcholinesterase
  • domestic guinea pig(100422792) acetylcholinesterase
  • sheep(101123006) acetylcholinesterase
  • cow(540446) acetylcholinesterase
  • domestic cat(493674) acetylcholinesterase
  • Zebrafish(114549) acetylcholinesterase
  • chicken(396388) acetylcholinesterase
  • naked mole-rat(101705724) acetylcholinesterase
  • dog(489828) acetylcholinesterase

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Small Molecule - Activator

Product Number
Description
Species
(NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine;chloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Pyridine-2-aldoxime methochloride, ,
Species
human

Small Molecule - Agonist

Product Number
Description
Species
Acetylthiocholine chloride, ≥99% (TLC), powder,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ACHE antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rat
Application
western blot
Anti-ACHE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-ACHE antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
cat, human, mouse, rabbit, rat
Application
ELISA
flow cytometry

immunofluorescence

western blot
Anti-ACHE, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-Acetylcholinesterase Antibody, clone AE-1, clone AE-1, Chemicon®, from mouse,
Species Reactivity
bovine, canine, chicken, guinea pig, human, monkey
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

Small Molecule - Inhibitor

Product Number
Description
Species
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate, ≥99%,
Species
human
Galanthamine hydrobromide from Lycoris sp., ≥94% (HPLC),
Species
human
Neostigmine methyl sulfate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Edrophonium chloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Pyridostigmine bromide, United States Pharmacopeia (USP) Reference Standard,
Species
human

Kits

Product Number
Description
Species
Acetylcholinesterase Activity Assay Kit, sufficient for 100 colorimetric tests,
Species
mouse, human

Proteins

Product Number
Description
Species
Acetylcholinesterase human, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (Lowry),
Species
human
Acetylcholinesterase from human erythrocytes, buffered aqueous solution, ≥500 units/mg protein (BCA),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ACHE,
Species
human