MilliporeSigma

FLT3

fms-related tyrosine kinase 3

Synonyms:
CD135, FLK-2, FLK2, STK1
Species:
UniProtKB ID:
Gene ID:
  • Human(2322) Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
  • Mouse(14255) FMS-like tyrosine kinase 3
  • Rat(140635) fms-related tyrosine kinase 3
  • Horse(100061780) fms-related tyrosine kinase 3
  • dog(486025) fms-related tyrosine kinase 3
  • chicken(100858422) fms-related tyrosine kinase 3
  • domestic cat(101099264) fms-related tyrosine kinase 3
  • Domestic Rabbit(100342842) fms-related tyrosine kinase 3
  • Zebrafish(566708) fms-related tyrosine kinase 3
  • sheep(101112331) fms-related tyrosine kinase 3
  • naked mole-rat(101713724) fms-related tyrosine kinase 3
  • cow(512700) fms-related tyrosine kinase 3
  • domestic guinea pig(100732047) fms-related tyrosine kinase 3

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ELISA

Product Number
Description
Species
Rhesus FLT3 ELISA Kit, for serum, plasma and cell culture supernatants,
Species
Human Flt-3 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-FLT3 (Ab-591) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Monoclonal Anti-CD135-APC antibody produced in mouse, clone BV10A4,
Species Reactivity
Application
flow cytometry
Anti-FLT3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
western blot
Anti-FLT3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
Monoclonal Anti-FLT3 antibody produced in mouse, clone 3H1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

Small Molecule - Inhibitor

Product Number
Description
Species
Symadex, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
FLT3 (571-993), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
Flt-3/Flk-2 ligand human, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC),
Species
human
Flt3 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE),
Species
human
Flt-3 Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant human Flt3, amino acids 564 -end. For use in Kinase Assays.,
Species
human
Flt-3 (D835Y) Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y, for use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Flt3,
Species
mouse
MISSION® esiRNA, targeting human FLT3,
Species
human