MilliporeSigma

HTR2A

5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled

Synonyms:
5-HT2A, HTR2
Species:
UniProtKB ID:
Gene ID:
  • Human(3356) Summary: This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • Mouse(15558) 5-hydroxytryptamine (serotonin) receptor 2A
  • Rat(29595) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • dog(403882) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • naked mole-rat(101708395) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • Horse(100009685) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • chicken(428070) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • domestic guinea pig(100135545) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • domestic cat(101081108) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • cow(407230) 5-hydroxytryptamine (serotonin) receptor 2A

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Small Molecule - Agonist

Product Number
Description
Species
Aripiprazole solution, 1.0 mg/mL (50:50 Methanol/Water with 1% 1N HCl), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
(±)-DOI hydrochloride, ≥98% (HPLC), solid,
Species
human
α-Methylserotonin maleate salt, ≥98% (HPLC),
Species
human
(R)(−)-DOI hydrochloride, ≥98% (HPLC), solid,
Species
human
Nortriptyline hydrochloride, ≥98% (HPLC), powder,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
2,2-Diphenylethylamine, 96%,
Species
rat
M100907, ≥98% (HPLC),
Species
human
Haloperidol, European Pharmacopoeia (EP) Reference Standard,
Species
human
SR-46349 hemifumarate salt, ≥98% (HPLC),
Species
human
Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-HTR2A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-5-HT-2A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry
Anti-Serotonin 2A (5-HT2A) Receptor (22-41) Rabbit pAb, liquid, Calbiochem®,
Species Reactivity
mouse, rat, sheep
Application
Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1, clone 9B11.1, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-HTR2A, affinity isolated antibody,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Mianserin hydrochloride, ,
Species
human
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human
Pimozide, ,
Species
human, mouse, rat
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Trazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Phenethylamine, ≥99%,
Species
rat, mouse, human
Phenethylamine, 99%,
Species
rat, mouse, human
Phenethylamine, purified by redistillation, ≥99.5%,
Species
rat, mouse, human

Small Molecule - Ligand

Product Number
Description
Species
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Mifepristone, ≥98%,
Species
human, mouse, rat
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

Small Molecule - Precursor

Product Number
Description
Species
5-Hydroxy-L-tryptophan, powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Htr2a,
Species
mouse