MilliporeSigma

MMP2

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Synonyms:
CLG4, CLG4A, MMP-II, MONA, TBE-1
Species:
UniProtKB ID:
Gene ID:
  • Human(4313) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(17390) matrix metallopeptidase 2
  • Rat(81686) matrix metallopeptidase 2
  • naked mole-rat(101696977) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • cow(282872) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • sheep(443115) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • chicken(386583) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • domestic guinea pig(100719361) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • dog(403733) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • Zebrafish(337179) matrix metalloproteinase 2
  • Horse(100033948) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • Domestic Rabbit(100009000) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • domestic cat(101098838) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • fruit fly(35997) Matrix metalloproteinase 2

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ELISA

Product Number
Description
Species
Human MMP-2 ELISA Kit, for serum, plasma, cell culture supernatant,
Species
human
Mouse MMP-2 ELISA Kit, for serum, plasma and cell culture supernatant,
Species
mouse
Rat MMP-2 ELISA, for serum, plasma and cell culture supernatants,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MMP2, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rat, sheep
Application
immunohistochemistry
western blot
Anti-MMP-2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-MMP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-MMP2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti- MMP2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
PD166793 hydrate, ≥98% (HPLC),
Species
human, rat, mouse
CP-471474, ≥98% (HPLC),
Species
human, rat, mouse
CP-101537, ≥98% (HPLC),
Species
human, rat, mouse
Marimastat, ≥98% (HPLC),
Species
human, rat, mouse

Proteins

Product Number
Description
Species
Matrix Metalloproteinase-2 human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Species
human
MMP-2 human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Species
human
Matrix Metalloproteinase-2 from mouse, recombinant, expressed in NSO cells, >95% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Mmp2,
Species
mouse
MISSION® esiRNA, targeting human MMP2,
Species
human