MilliporeSigma

TYMS

thymidylate synthetase

Synonyms:
HST422, TMS, TS
Species:
UniProtKB ID:
Gene ID:
  • Human(7298) Summary: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
  • Mouse(22171) thymidylate synthase
  • Rat(29261) thymidylate synthetase
  • naked mole-rat(101721263) thymidylate synthetase
  • domestic guinea pig(100720541) thymidylate synthetase
  • Zebrafish(81540) thymidylate synthase
  • chicken(421060) thymidylate synthetase
  • cow(507631) thymidylate synthetase
  • domestic cat(101091231) thymidylate synthetase
  • dog(607417) thymidylate synthetase

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-TYMS antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
Anti-TYMS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-TYMS antibody produced in mouse, clone 3A1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-TYMS antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-TYMS antibody produced in mouse, clone 2B2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Capecitabine, British Pharmacopoeia (BP) Reference Standard,
Species
human
Fluorouracil, British Pharmacopoeia (BP) Reference Standard,
Species
human
5-Fluorouracil, analytical standard,
Species
human
Capecitabine, European Pharmacopoeia (EP) Reference Standard,
Species
human
Floxuridine, United States Pharmacopeia (USP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human TYMS,
Species
human
MISSION® esiRNA, targeting mouse Tyms,
Species
mouse