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Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids.

Organic & biomolecular chemistry (2011-08-17)
Yong-Chul Jeong, Muhammad Anwar, Tuan Minh Nguyen, Benjamin Song Wei Tan, Christina Li Lin Chai, Mark G Moloney
RESUMEN

An efficient strategy for the control of the chemoselectivity in Dieckmann ring closures leading to tetramic acids derived from serine and α-methyl serine is reported, and this provides pathways to diversely substituted systems from a common starting material.