Discovery of a β-glucosidase inhibitor from a chemically engineered extract prepared through sulfonylation.

Discovery of a β-glucosidase inhibitor from a chemically engineered extract prepared through sulfonylation.

Molecular diversity (2011-01-06)

Mario O Salazar, Oscar Micheloni, Andrea M Escalante, Ricardo L E Furlan

PMID21207143

RESUMEN

A semisynthetic β-glucosidase inhibitor was identified from a chemically engineered extract prepared by reaction with benzenesulfonyl chloride. The structure includes a natural histamine portion and a benzenesulfonyl portion introduced during the diversification step.

MATERIALES

Número de producto

Marca

Descripción del producto

108138

Sigma-Aldrich

Benzenesulfonyl chloride, 99%

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108111

Sigma-Aldrich

Benzenesulfonyl chloride, 96%

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12620

Sigma-Aldrich

Benzenesulfonyl chloride, derivatization grade (HPLC)

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