- Facile Route to Tetrasubstituted Pyrazoles Utilizing Ceric Ammonium Nitrate.
Facile Route to Tetrasubstituted Pyrazoles Utilizing Ceric Ammonium Nitrate.
Synlett : accounts and rapid communications in synthetic organic chemistry (2009-01-01)
James J Devery, Pramod K Mohanta, Brian M Casey, Robert A Flowers
PMID21151843
RESUMEN
A convenient approach for the synthesis of tetrasubstituted pyrazoles is described. The method involves the treatment of 1,3-diketones and allyltrimethylsilane with CAN followed by cerium-catalyzed addition of substituted hydrazines to construct pyrazoles in good yields.