A0189

Amyloid β Protein Fragment 1-38

Name: Amyloid β Protein Fragment 1-38
Brand: SIGMA

≥95% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):

C₁₈₄H₂₇₇N₅₁O₅₆S

CAS Number:

131438-74-9

Molecular Weight:

4131.54

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00166810

Key Documents

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Product Name

Amyloid β Protein Fragment 1-38, ≥95% (HPLC), powder

assay

≥95% (HPLC)

form

powder

color

white

solubility

H₂O: 1 mg/mL

UniProt accession no.

P05067

storage temp.

−20°C

Quality Level

200

Gene Information

human ... APP(351)

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This Item	A4848	A1472	A7973
Sigma-Aldrich A0189 Amyloid β Protein Fragment 1-38	Sigma-Aldrich A4848 Amyloid β-Protein Fragment 17-40	Sigma-Aldrich A1472 MCA-[Asn⁶⁷⁰, Leu⁶⁷¹]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676-DNP-Lys-Arg-Arg-NH₂	Sigma-Aldrich A7973 [Arg¹³] Amyloid-β-Protein Fragment 1-40
form powder	form lyophilized powder	form powder	form lyophilized powder
assay ≥95% (HPLC)	assay ≥87% (HPLC)	assay ≥90% (HPLC)	assay ≥80% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 1 mg/mL	solubility H₂O: soluble	solubility -	solubility H₂O: soluble
color white	color -	color -	color -

Biochem/physiol Actions

β-Amyloid peptide that forms cross-β-sheet fibrils of 70-90 Å diameter with similar antigenicity as those found in Alzheimer′s disease.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Morphology and antibody recognition of synthetic beta-amyloid peptides.

P E Fraser et al.

Journal of neuroscience research, 28(4), 474-485 (1991-04-01)

To elucidate the relationship between amyloid fibril formation in Alzheimer disease (AD) and the primary structure of the beta-amyloid protein (beta-AP), we investigated the ability of peptides sharing sequences with beta-AP to form fibrils in vitro and to recognize anti-beta-amyloid

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity.

M P Mattson et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(2), 376-389 (1992-02-01)

In Alzheimer's disease (AD), abnormal accumulations of beta-amyloid are present in the brain and degenerating neurons exhibit cytoskeletal aberrations (neurofibrillary tangles). Roles for beta-amyloid in the neuronal degeneration of AD have been suggested based on recent data obtained in rodent

beta-Amyloid induction of gelatinase B secretion in cultured microglia: inhibition by dexamethasone and indomethacin.

P E Gottschall

Neuroreport, 7(18), 3077-3080 (1996-11-25)

Since administration of anti-inflammatory drugs has been reported to possibly slow the progression of Alzheimer's disease, an effort was made to define effector functions induced by beta-amyloid (A beta) which may be inhibited by these drugs. Rat microglia in culture

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