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Merck

496219

N,N-Diisopropylethylamine

99.5%, biotech. grade

Synonym(s):

N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine, ‘Hünig’s base’

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100 ML

R 2,020.76

500 ML

R 6,627.74

R 2,020.76

List PriceR 2,062.00

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About This Item

Linear Formula:
[(CH3)2CH]2NC2H5
CAS Number:
Molecular Weight:
129.24
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
230-392-0
MDL number:
Grade:
biotech. grade
Assay:
99.5%
Application(s):
peptide synthesis
Bp:
127 °C (lit.)
Vapor pressure:
31 mmHg ( 37.7 °C)

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Product Name

N,N-Diisopropylethylamine, 99.5%, biotech. grade

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

SMILES string

CCN(C(C)C)C(C)C

grade

biotech. grade

vapor pressure

31 mmHg ( 37.7 °C)

assay

99.5%

form

liquid

impurities

<0.050% water

color

APHA: <20

refractive index

n20/D 1.414 (lit.)

pH

12.3 (20 °C)

bp

127 °C (lit.)

mp

<−50 °C (lit.)

solubility

water: soluble 4.01 g/L at 20 °C

density

0.742 g/mL at 25 °C (lit.)

application(s)

peptide synthesis

Quality Level

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1 of 4

This Item
387649D12580603440
grade

biotech. grade

grade

-

grade

-

grade

BASF quality

assay

99.5%

assay

99.5%

assay

≥99%

assay

≥98.0%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

application(s)

peptide synthesis

application(s)

-

application(s)

-

application(s)

-

solubility

water: soluble 4.01 g/L at 20 °C

solubility

water: soluble 4.01 g/L at 20 °C

solubility

-

solubility

-

form

liquid

form

liquid

form

liquid

form

liquid

Application

N, N-Diisopropylethylamine can be used as a base:
  • In the palladium (0)-catalyzed alkoxy carbonylation of allyl phosphates and acetate.
  • In the selective enolate formation along with boryl triflates.
  • In the C–N coupling of aryl halides with nitroarenes in the presence of nickel catalyst.

N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.[1]

General description

N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.
N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.
Our biotech solvents offer exceptional quality for reliable RNA extraction, ensuring optimal laboratory performance. With low water content and minimal residue, give clean UV spectra to minimize contamination.
  • High-Quality Biotech Solvents: Designed for optimal laboratory performance with low water content and minimal residues.
  • Ideal for RNA Extraction: Essential for genetic testing and research applications like PCR.
  • Ensures Integrity of Genetic Material: Promotes reliable and reproducible results.
  • Industry Compliant: Suitable for both academic and commercial laboratories, enhancing research efficiency.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.1 °F

flash_point_c

9.5 °C


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Lipase-catalysed synthesis of olvanil in organic solvents.
Reyes-Duarte D, et al.
Biotechnology Letters, 24(24), 2057-2061 (2002)
Asymmetric Hydrogenation of α,β-Unsaturated Nitriles with Base-Activated Iridium N, P Ligand Complexes
Muller MA and Pfaltz A.
Angewandte Chemie (International Edition in English), 126(33), 8812-8815 (2014)
Facile and Gram-scale Synthesis of Metal-free Catalysts: Toward Realistic Applications for Fuel Cells.
Kim OH, et al.
Scientific Reports, 5 (2015)
Alexandre Yersin et al.
Biophysical journal, 94(1), 230-240 (2007-09-18)
Interaction between the iron transporter protein transferrin (Tf) and its receptor at the cell surface is fundamental for most living organisms. Tf receptor (TfR) binds iron-loaded Tf (holo-Tf) and transports it to endosomes, where acidic pH favors iron release. Iron-free
Irina Naletova et al.
Cancers, 11(9) (2019-09-11)
Angiogenin (ANG), an endogenous protein that plays a key role in cell growth and survival, has been scrutinised here as promising nanomedicine tool for the modulation of pro-/anti-angiogenic processes in brain cancer therapy. Specifically, peptide fragments from the putative cell

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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