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NOS1

nitric oxide synthase 1 (neuronal)

Synonyms:
IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Species:
UniProtKB ID:
Gene ID:
  • Human(4842) Summary: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
  • Mouse(18125) nitric oxide synthase 1, neuronal
  • Rat(24598) nitric oxide synthase 1, neuronal
  • Domestic Rabbit(100009243) nitric oxide synthase 1 (neuronal)
  • naked mole-rat(101711993) nitric oxide synthase 1 (neuronal)
  • cow(536132) nitric oxide synthase 1 (neuronal)
  • domestic cat(101100342) nitric oxide synthase 1 (neuronal)
  • Zebrafish(60658) nitric oxide synthase 1 (neuronal)
  • Horse(100051079) nitric oxide synthase 1 (neuronal)
  • dog(477498) nitric oxide synthase 1 (neuronal)
  • chicken(427721) nitric oxide synthase 1 (neuronal)
  • domestic guinea pig(100729682) nitric oxide synthase 1 (neuronal)

Custom & Knockdown Gene Products

Small Molecule - Antagonist

Product Number
Description
Species
(+)-Thalidomide, ≥98% (HPLC), powder,
Species
human, mouse, rat
Nω-Nitro-L-arginine, ≥98% (TLC),
Species
rat, mouse, human
Pentamidine isethionate salt, powder,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Nitric Oxide Synthase I Antibody, Chemicon®, from rabbit,
Species Reactivity
bovine, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-Nitrotyrosine Antibody, clone 2A8.2, clone 2A8.2, Chemicon®, from mouse,
Species Reactivity
all
Application
immunohistochemistry
western blot
Anti-Nitrotyrosine antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
wide range
Application
ELISA
immunofluorescence

immunohistochemistry

microarray

western blot
Monoclonal Anti-Nitrotyrosine antibody produced in mouse, clone 39B6, 1 mg/mL, purified immunoglobulin,
Species Reactivity
dog, human, mouse, rat
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-NOS1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence

Small Molecule - Inhibitor

Product Number
Description
Species
Spermidine trihydrochloride, ≥98% (TLC),
Species
human
4-Nitrocatechol, ≥96.0%,
Species
rat
3,5-Di-tert-butyl-4-hydroxytoluene, analytical standard,
Species
rat, human
L-Arginine, ,
Species
rat, human
L-Arginine, reagent grade, ≥98%,
Species
rat, human

Kits

Product Number
Description
Species
Nitric Oxide Synthase Detection System, Fluorimetric, sufficient for 200 reactions,
Species
human

Small Molecule - Precursor

Product Number
Description
Species
L-Arginine, ,
Species
rat, human
L-Arginine, reagent grade, ≥98%,
Species
rat, human
L-Arginine, BioUltra, ≥99.5% (NT),
Species
rat, human
L-Arginine, EMPROVE® EXPERT, EP, USP,
Species
rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Nos1,
Species
mouse