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Merck

KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

Sinonimi:
ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1
Specie:
ID UniProtKB:
ID gene:
  • Human(3757) Summary: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(16511) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Rat(117018) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Zebrafish(405763) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • naked mole-rat(101711977) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic cat(101081621) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Horse(100064000) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Domestic Rabbit(100009242) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • dog(403761) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic guinea pig(100135563) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • cow(539971) potassium voltage-gated channel, subfamily H (eag-related), member 2

Custom & Knockdown Gene Products

Small Molecule - Antagonist

Numero di prodotto
Descrizione
Specie
Sotalol hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Sotalol hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Specie
human
Glibenclamide, meets USP testing specifications,
Specie
rat, human
(±)-Sotalol hydrochloride, ≥98% (TLC), powder,
Specie
human
Glibenclamide, ≥99% (HPLC),
Specie
rat, human

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-Potassium Channel KV11.1 (HERG) Extracellular-FITC, affinity isolated antibody, lyophilized powder,
Reattività con
human
Applicazione
flow cytometry
immunocytochemistry
Anti-Potassium Channel HERG Antibody, CT, Chemicon®, from rabbit,
Reattività con
human
Applicazione
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-KCNH2 antibody produced in rabbit, affinity isolated antibody,
Reattività con
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Applicazione
western blot
Anti-Potassium Channel ERG1 Antibody, CT, Chemicon®, from rabbit,
Reattività con
human, mouse, rat
Applicazione
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reattività con
human
Applicazione
flow cytometry
immunocytochemistry

western blot

Small Molecule - Blocker

Numero di prodotto
Descrizione
Specie
Ibutilide hemifumarate salt, ≥98% (HPLC),
Specie
human
Dofetilide, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Amiodarone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human
Ibutilide fumarate, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 885.23 ([(C20H36N2O3S)2 . C4H4O4]),
Specie
human
Sotalol hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human

Small Molecule - Inhibitor

Numero di prodotto
Descrizione
Specie
Loratadine, ≥98% (HPLC), powder,
Specie
rat, human
Terfenadine, ,
Specie
mouse, rat, human
Cocaine free base, ,
Specie
mouse, rat, human
Pimozide, ,
Specie
human, mouse, rat
Haloperidol, powder,
Specie
human, rat

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human KCNH2,
Specie
human