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Merck

KCNJ1

potassium inwardly-rectifying channel, subfamily J, member 1

Sinonimi:
KIR1.1, ROMK, ROMK1
Specie:
ID UniProtKB:
ID gene:
  • Human(3758) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(56379) potassium inwardly-rectifying channel, subfamily J, member 1
  • Rat(24521) potassium inwardly-rectifying channel, subfamily J, member 1
  • chicken(428236) potassium inwardly-rectifying channel, subfamily J, member 1
  • Horse(100072580) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic cat(101091140) potassium inwardly-rectifying channel, subfamily J, member 1
  • cow(539250) potassium inwardly-rectifying channel, subfamily J, member 1
  • dog(489285) potassium inwardly-rectifying channel, subfamily J, member 1
  • naked mole-rat(101720253) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic guinea pig(100722828) potassium inwardly-rectifying channel, subfamily J, member 1

Custom & Knockdown Gene Products

Small Molecule - Activator

Numero di prodotto
Descrizione
Specie
Diazoxide, ,
Specie
rat, mouse, human

Small Molecule - Antagonist

Numero di prodotto
Descrizione
Specie
Glibenclamide, meets USP testing specifications,
Specie
rat, human
Cromakalim, ,
Specie
rat
Glibenclamide, ≥99% (HPLC),
Specie
rat, human
Chlorpropamide, analytical standard, ≥97%,
Specie
human, mouse
Tolbutamide, analytical standard,
Specie
human, mouse

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-KCNJ1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-KCNJ1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot
Anti-KCNJ1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
dog, guinea pig, horse, human, rabbit, rat
Applicazione
western blot

Small Molecule - Blocker

Numero di prodotto
Descrizione
Specie
Gliclazide, powder, ≥98%,
Specie
human
Glipizide, solid,
Specie
human
Glimepiride, ≥98% (HPLC), solid,
Specie
human
Repaglinide, ≥98% (HPLC), solid,
Specie
human
Glibenclamide, meets USP testing specifications,
Specie
rat, human

Small Molecule - Inhibitor

Numero di prodotto
Descrizione
Specie
Linopirdine, ≥98% (HPLC),
Specie
rat
VU591, ≥98% (HPLC),
Specie
human
Tertiapin-Q trifluoroacetate salt, ≥97% (HPLC),
Specie
rat, human, mouse
Chlorpropamide, analytical standard, ≥97%,
Specie
human, mouse
Tolbutamide, analytical standard,
Specie
human, mouse

Small Molecule - Ligand

Numero di prodotto
Descrizione
Specie
Glipizide, solid,
Specie
human
Glimepiride, ≥98% (HPLC), solid,
Specie
human
Glibenclamide, ≥99% (HPLC),
Specie
rat, human
Chlorpropamide, analytical standard, ≥97%,
Specie
human, mouse

Small Molecule - Opener

Numero di prodotto
Descrizione
Specie
Minoxidil, ≥99% (TLC),
Specie
human
Diazoxide, ,
Specie
rat, mouse, human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human KCNJ1,
Specie
human