TIRAP
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Synonyme:
BACTS1, Mal, MyD88-2, wyatt
Spezies:
Human TIRAP (114609), Mouse Tirap (117149), Rat Tirap (680127), sheep TIRAP (101118490), naked mole-rat Tirap (101715320), Zebrafish tirap (403148), cow TIRAP (531079), domestic cat TIRAP (101088688), domestic guinea pig Tirap (100732763), chicken TIRAP (419715)
UniProtKB-ID:
Gen-ID:
- Human(114609) Summary: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
- Mouse(117149) toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
- Rat(680127) toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
- sheep(101118490) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- naked mole-rat(101715320) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- Zebrafish(403148) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- cow(531079) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- domestic cat(101088688) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- domestic guinea pig(100732763) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- chicken(419715) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- dog(609544) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-TIRAP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-phospho-TIRAP (pTyr86) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry
immunohistochemistry
Anti-TIRAP antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunohistochemistry
western blot
western blot
Anti-TIRAP (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot