901425
White-Clark catalyst
powder
동의어(들):
[MnIII(ClPc)]Cl
조직 및 계약 가격을 보려면 를 클릭합니다.
크기 선택
보기 변경
| 팩 크기/SKU | 재고 정보 | 가격 (VAT 별도) |
|---|---|---|
100 mg | 구입 가능 여부는 고객센터에 문의하십시오. | ₩155,803 |
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C32Cl17MnN8
CAS 번호:
Molecular Weight:
1154.04
MDL number:
NACRES:
NA.22
UNSPSC Code:
12161600
제품 이름
White-Clark catalyst,
form
powder
reaction suitability
reaction type: Cross Couplings, reagent type: catalyst
core: manganese
Application
This catalyst is useful for late-stage functionalization of complex compounds through C-H amination. This catalyst is highly reactive and selective for amination at benzylic positions. The benzylic amination is highly selective over tertiary amination. In substrates with multiple benzylic sites, the preference is for amination at the least sterically encumbered and most electron rich site, irrespective of bond dissociation energy (BDE). Substrates containing basic nitrogen (tertiary amines, pyridine, benzimidazole) can be effectively protected for the first time using this catalyst with a Brønsted (HBF4) or Lewis acid (BF3), to give remotely aminated products. Late-stage amination has been demonstrated on a series of drugs and drug-like molecules, including citalopram, analogs of estrone and dextromethorphan, and biflavanoids, many of which cannot be accessed by other amination methods due to the presence of basic nitrogens.
Legal Information
This product is patent pending under application #62/569,872.
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이 품목 | |
|---|---|
| reaction suitability reaction type: Cross Couplings, reagent type: catalyst | reaction suitability - |
| form powder | form powder or solid |
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저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable