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5.00554

MHY1485

≥97% (HPLC), solid, mTOR activator, Calbiochem®

Synonym(s):

mTOR Activator, MHY1485, 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III

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Size/SKUAvailabilityPrice
10 mg
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$227.00

About This Item

Empirical Formula (Hill Notation):
C17H21N7O4
CAS Number:
326914-06-1
Molecular Weight:
387.39
MDL number:
MFCD06591335
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
2026662
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light

$227.00

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Product Name

mTOR Activator, MHY1485,

assay

≥97% (HPLC)

Quality Segment

100

form

solid

potency

~2 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 12.5 mg/mL

storage temp.

2-8°C

SMILES string

C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O

InChI key

VHYUALWDIXAVIZ-UHFFFAOYSA-N

General description

MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.

Application

mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).

Biochem/physiol Actions

Cell permeable: yes
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Choi, Y. J., et al. 2012. PLoS. One.7, e43418.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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mTOR Activator, MHY1485

Sigma-Aldrich

5.00554

mTOR Activator, MHY1485

mTOR Kinase Inhibitor II, WYE-354 The mTOR Kinase Inhibitor II, WYE-354, also referenced under CAS 1062169-56-5, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

475986

mTOR Kinase Inhibitor II, WYE-354

Beclin-1 Activator I, TAT-Beclin-1

Sigma-Aldrich

5.06048

Beclin-1 Activator I, TAT-Beclin-1

mTOR Inhibitor XI, Torin1 mTOR Inhibitor XI, Torin1, CAS 1222998-36-8, is a cell-permeable, highly potent, ATP-competitive inhibitor of mTOR and DNA-PK (IC50 = 4.32 and 6.34 nM, respectively).

Sigma-Aldrich

475991

mTOR Inhibitor XI, Torin1

description

-

description

The mTOR Kinase Inhibitor II, WYE-354, also referenced under CAS 1062169-56-5, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

-

description

mTOR Inhibitor XI, Torin1, CAS 1222998-36-8, is a cell-permeable, highly potent, ATP-competitive inhibitor of mTOR and DNA-PK (IC50 = 4.32 and 6.34 nM, respectively).

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥99% (HPLC)

form

solid

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 12.5 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 50 mg/mL, water: 50 mg/mL

solubility

DMSO: 2 mg/mL

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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