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Anti-LAMP-2 Antibody, clone ABL-93

Name: Anti-LAMP-2 Antibody, clone ABL-93
Brand: MM
Price: 534 USD
Availability: InStock

clone ABL-93, from rat

Synonym(s):

lysosomal-associated membrane protein 2, CD107 antigen-like family member B, CD107b antigen

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Size/SKU	Availability	Price
100 μg	Check Cart for Availability	$534.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

ABL-93, monoclonal

Application:

IF, IP, WB

Citations:

$534.00

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Properties

biological source

rat

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

ABL-93, monoclonal

species reactivity

mouse

technique(s)

immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_001017959

UniProt accession no.

P17047

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Lamp2(16784)

Description

General description

Lysosome-associated membrane protein 2 (LAMP-2) is a highly glycosolated protein belonging to the lysosome-associated membrane protein family. This group pf proteins composes a significant portion of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-2 is a profuse and critical component of the lysosomal membrane as it has been implicated in playing a role in lysosomal biogenesis. It also appears to be involved in later stages of phagocytosis and autophagy, where it may act to protect the lysosomal membrane from being digested, assist in signal transduction, moderate levels of acidity within the lysosomal environment, and participate in adhesion. Mutations in LAMP-2 expression have been associated with lysosomal storage diseases or LSDs, along with Danon disease, an X-linked disorder characterized by skeletal myopathy, mental retardation, and hypertrophic cardiomyopathy.

~ 80 kDa observed MW. The calculated MW is 45 kDa LAMP-2 is heavily glycosoated and has been routinely observed at MW′s of 80-120 kDa based on publication data, (Chen, 1985; Ferguson, 2009).

Immunogen

Purified glycoproteins from NIH/3T3 cells, corresponding to mouse LAMP-2.

Application

Anti-LAMP-2 Antibody, clone ABL-93 is an antibody against LAMP-2 for use in WB, IP & IF.

Immunoprecipitation Analysis: This antibody has been shown to immunoprecipitate LAMP-2 in HaNIH cells, (Chen, 1985).

Immunofluorescence Analysis: This antibody has been shown to detect LAMP-2 in mouse brain, (Ferguson, 2009).

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Biochem/physiol Actions

This antibody recognizes LAMP-2.

Physical form

Format: Purified

Protein G

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
NIH/3T3 cell lysate

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-2 in 10 µg of NIH/3T3 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	MABC1766	MABC39	MABC44
Sigma-Aldrich MABC40 Anti-LAMP-2 Antibody, clone ABL-93	Sigma-Aldrich MABC1766 Anti-LAMP2/CD107b Antibody, clone H4B4	Sigma-Aldrich MABC39 Anti-LAMP-1 (CD107a) Antibody, clone 1D4B	Sigma-Aldrich MABC44 Anti-LAMP-3 Antibody, clone 16H11.2
description clone ABL-93, from rat	description -	description clone 1D4B, from rat	description clone 16H11.2, from mouse
Gene Information mouse ... Lamp2(16784)	Gene Information human ... LAMP2(3920)	Gene Information mouse ... Lamp1(16783)	Gene Information human ... LAMP3(27074)
antibody form purified immunoglobulin	antibody form purified antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone ABL-93, monoclonal	clone H4B4, monoclonal	clone 1D4B, monoclonal	clone 16H11.2, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rat	biological source mouse	biological source rat	biological source mouse
species reactivity mouse	species reactivity mouse, rat, human, monkey	species reactivity mouse	species reactivity human

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c