Product SBR00053 is a ready-made solution in ethanol designed for media supplementation. Product V3501 is neat Vitamin K1 that has been utilized in the preparation of culture media, as indicated by researchers in the citation on the product page. The solution may be easier to work with, as vitamin K1 is a viscous liquid. Please do keep in mind that vitamin K1 is light sensitive.
95271
Vitamin K1
BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers
Synonym(s):
2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K1(20)
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About This Item
Empirical Formula (Hill Notation):
C31H46O2
CAS Number:
Molecular Weight:
450.70
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
201-564-2
Beilstein/REAXYS Number:
2568816
MDL number:
eCl@ss:
34058015
Pricing and availability is not currently available.
biological source
synthetic
Quality Level
product line
BioXtra
assay
≥99.0% (sum of isomers, HPLC)
form
viscous liquid
impurities
≤20% cis-isomer
ign. residue
≤0.1% (as SO4)
color
light green-yellow to dark green-yellow, light yellow to dark yellow
refractive index
n20/D 1.527 (lit.)
mp
−20 °C (lit.)
density
0.984 g/mL at 25 °C (lit.)
cation traces
Al: ≤5 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤100 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤10 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg
storage temp.
2-8°C
SMILES string
O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O
InChI
1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
InChI key
MBWXNTAXLNYFJB-NKFFZRIASA-N
General description
Vitamin K1, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin.
Application
<ul>
<li><strong>Nutritional strategies for musculoskeletal health:</strong> Nutritional strategies, including Vitamin K1, optimize musculoskeletal health for fall and fracture prevention beyond traditional nutrients like calcium and vitamin D (Webster et al., 2023 doi:10.1016/j.bonr.2023.101684).</li>
<li><strong>Role in coagulation and bone health:</strong> A comprehensive review highlights Vitamin K1′s role in reducing cardiovascular risks and details its biochemical interactions affecting coagulation and bone health (Zhao et al., 2024 doi:10.1017/jns.2023.106).</li>
</ul>
<li><strong>Nutritional strategies for musculoskeletal health:</strong> Nutritional strategies, including Vitamin K1, optimize musculoskeletal health for fall and fracture prevention beyond traditional nutrients like calcium and vitamin D (Webster et al., 2023 doi:10.1016/j.bonr.2023.101684).</li>
<li><strong>Role in coagulation and bone health:</strong> A comprehensive review highlights Vitamin K1′s role in reducing cardiovascular risks and details its biochemical interactions affecting coagulation and bone health (Zhao et al., 2024 doi:10.1017/jns.2023.106).</li>
</ul>
Biochem/physiol Actions
Vitamin K1 plays a role as a cofactor in the synthesis of γ- carboxy glutamate (Gla), formation of coagulation factors II (prothrombin), VII, IX and X.
Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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This Item | |||
|---|---|---|---|
| biological source synthetic | biological source synthetic (organic | biological source - | biological source - |
| assay ≥99.0% (sum of isomers, HPLC) | assay - | assay - | assay - |
| form viscous liquid | form viscous liquid | form liquid | form liquid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −70°C | storage temp. 15-25°C |
| color light green-yellow to dark green-yellow, light yellow to dark yellow | color , Yellow to Very Dark Yellow to Very Dark Orange | color - | color - |
| Quality Level 200 | Quality Level 100 | Quality Level 300 | Quality Level 500 |
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
Schurgers L J, et al.
Blood, 109(8), 3279-3283 (2006)
Metabolism of vitamin K1 (phylloquinone) in man.
Barkhan P and Shearer M J
Proceedings of the Royal Society of Medicine, 70(2), 93-93 (1977)
Waldemar Seel et al.
Scientific reports, 10(1), 330-330 (2020-01-17)
Carotenoids are associated with several important biological functions as antenna pigments in photosynthesis or protectives against oxidative stress. Occasionally they were also discussed as part of the cold adaptation mechanism of bacteria. For two Staphylococcus xylosus strains we demonstrated an
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 95271-250MG | 04061833315804 |
| 95271-1G | 04061833315798 |
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I would like to order Vitamin K1 to add in the media for cultivation of ananerobic mircobes. there are somany Vitamin K1 everything with same cas number but thy vary in price iam not sure which one is suitable for bacterial cultivation?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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I buy the 250mg bottle and I was wondering about the concentration of the bottle because it arrives as a viscous liquid. It is very important to me to know about the concentration of the liquid to work with it.
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Product No. 95271 contains neat Vitamin K1 specified at ≥99.0% purity. Using the minimum specified purity, density, and molecular weight of Vitamin K1, this neat product would have a concentration of about 2.16 M at 25 °C.
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