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Anti-S100B Antibody

Name: Anti-S100B Antibody
Brand: SIGMA
Price: 573 USD
Availability: InStock

Enhanced Validation

Prestige Antibodies^® Powered by Atlas Antibodies, mouse monoclonal, CL2720

Synonym(s):

S100beta

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Size/SKU	Availability	Price
100 μL	Check Cart for Availability	$573.00

About This Item

UNSPSC Code:

12352203

Human Protein Atlas Number:

AMAB91038

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

CL2720, monoclonal

Application:

IHC

Citations:

$573.00

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Properties

Product Name

Monoclonal Anti-S100B antibody produced in mouse, Prestige Antibodies^® Powered by Atlas Antibodies, clone CL2720, purified immunoglobulin, buffered aqueous glycerol solution

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CL2720, monoclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human, rat, mouse

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

concentration

1 mg/mL

technique(s)

immunoblotting: 1 μg/mL, immunohistochemistry: 1:500- 1:1000

pH range

7.2-7.4

isotype

IgG1

UniProt accession no.

P04271

application(s)

research pathology

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... S100B(6285)

Description

General description

The gene S-100 β subunit (S100B) is a 21kDa acidic protein. It is encoded by the gene mapped to human chromosome 21q22.3. The gene codes for a calcium-binding protein and is a member of S100 family of calcium-binding proteins. The encoded protein is produced predominantly by astrocytes. S100B is a homodimer with two β subunits.

Immunogen

S100 calcium binding protein B

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collecation of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Monoclonal Anti-S100B antibody produced in mouse has been used in immunocytochemistry and immunofluorescence studies.

Biochem/physiol Actions

S-100 β subunit (S100B) exerts paracrine and autocrine effects on neurons and glia. At nanomolar concentrations, the encoded protein promotes neurite outgrowth and increases survival of neurons during development. S100B serves as a marker of melanocyte cytotoxicity. In addition, it also acts as a serum marker in endocrine resistant breast cancer and Nonsegmental Vitiligo. Decreased expression of S100B has been observed in chronic liver disease patients.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
Protein array of 364 human recombinant protein fragments.

Physical form

100UL pack size is provided in a solution, in PBS(phosphate-buffered saline), pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Large pack size of 1ml (at 1mg/ml) is available in PBS only, purified, biocide free, carrier free and glycerol free. Order here

Preparation Note

Upon arrival, mix gently and aliquot to avoid repeated freeze-thaw cycles

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	HPA015768	SAB5500172	S2657
Sigma-Aldrich AMAB91038 Monoclonal Anti-S100B antibody produced in mouse	Sigma-Aldrich HPA015768 Anti-S100B antibody produced in rabbit	Sigma-Aldrich SAB5500172 Anti-S100 Beta antibody, Rabbit monoclonal	Sigma-Aldrich S2657 Anti-S-100 (β-Subunit) antibody, Mouse monoclonal
description Prestige Antibodies^® Powered by Atlas Antibodies, clone CL2720, purified immunoglobulin, buffered aqueous glycerol solution	description affinity isolated antibody, buffered aqueous glycerol solution	description recombinant, expressed in proprietary host, clone SP127, affinity isolated antibody	description clone SH-B4, purified from hybridoma cell culture
clone CL2720, monoclonal	clone polyclonal	clone SP127, monoclonal	clone SH-B4, monoclonal
species reactivity human, rat, mouse	species reactivity human	species reactivity human (tested)	species reactivity sheep, bovine, goat, pig, feline, rabbit, rat, canine, human
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form (Solution in 0.01M phosphate buffered saline pH 7.4, containing 15mM sodium azide as a preservative)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... S100B(6285)	Gene Information human ... S100B(6285)	Gene Information human ... S100B(6285)	Gene Information human ... S100B(6285) rat ... S100b(25742)
biological source mouse	biological source rabbit	biological source rabbit	biological source mouse

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Storage Class

10 - Combustible liquids

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WGK 1

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