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F1554

Anti-FXR2 antibody, Mouse monoclonal

Name: Anti-FXR2 antibody, Mouse monoclonal
Brand: SIGMA

clone A42, purified from hybridoma cell culture

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A propos de cet article

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02262924

Conjugate:

unconjugated

Clone:

A42, monoclonal

Application:

ARR, ICC, IHC, IP, WB

Citations:

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Propriétés

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

A42, monoclonal

form

buffered aqueous solution

mol wt

antigen ~74 kDa

species reactivity

human

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, microarray: suitable, western blot: 2-4 μg/mL using total cell extract of HEK 293T cells

isotype

IgG1

UniProt accession no.

P51116

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FXR2(9513)

Description

General description

Monoclonal Anti-FXR2 (mouse IgG1 isotype) is derived from the hybridoma A42 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with human Fragile X mental retardation syndrome-related protein 2 (FXR2) recombinant protein. FXR2 gene is located on human chromosome 17 and its protein is localized mainly in the cytoplasm. FXR2 is expressed along with other proteins in the cytoplasm of neurons. It is characterized with two KH domains and one RGG box that together with fragile X mental retardation 1 (FMR1) bind to RNA. FXR2 is highly expressed in brain and testis.

Immunogen

human FXR2 recombinant protein.

Application

Anti-FXR2 antibody, Mouse monoclonal may be used in:

immunoblotting
immunoprecipitation [1]
immunocytochemistry
immunohistochemistry
co-immunoprecipitation
immunofluorescence [2]
sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)

Biochem/physiol Actions

Fragile X mental retardation syndrome-related protein 2 (FXR2) is capable of forming heteromers with the others and can also form homomers. It has an independent function in tissues during embryonic development and adult life.

Fragile X mental retardation syndrome-related protein 2 (FXR2) knockout mice are hyperactive in the open-field test, impaired on the rotarod test, have reduced levels of prepulse inhibition, display less contextual conditioned fear, are impaired at locating the hidden platform in the Morris water task, and less sensitive to heat stimulus.

Monoclonal Anti-FXR2 recognizes human, monkey, bovine, canine, rat, hamster, and mouse, FXR2, ~74 kDa, and does not crossreact with FMR or FXR1.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Preparation Note

For continuous use, store at 2–8 °C for up to one month. For prolonged storage, freeze in working aliquots. Repeated freezing and thawing, or storage in frost-free freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Cet article	SAB1411669	SAB4200597	R9778
Sigma-Aldrich F1554 Anti-FXR2 antibody, Mouse monoclonal	Sigma-Aldrich SAB1411669 Anti-FXR2 antibody produced in rabbit	Sigma-Aldrich SAB4200597 Monoclonal Anti-FMR1 antibody produced in mouse	Sigma-Aldrich R9778 Anti-hnRNP-A1 antibody, Mouse monoclonal
antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source rabbit	biological source mouse	biological source mouse
clone A42, monoclonal	clone polyclonal	clone FMR2.5, monoclonal	clone 4B10, monoclonal
Gene Information human ... FXR2(9513)	Gene Information human ... FXR2(9513)	Gene Information human ... FMR1(2332) mouse ... Fmr1(14265) rat ... Fmr1(24948)	Gene Information human ... HNRNPA1(3178)
species reactivity human	species reactivity human, mouse	species reactivity rat, human, mouse, hamster	species reactivity bovine, human, canine

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10 - Combustible liquids

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Contenu apparenté

Data Sheet - F1554

Instructions

Knockout mouse model for Fxr2: a model for mental retardation

Bontekoe CJM, et al.

Human Molecular Genetics, 11(5), 487-498 (2002)

Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway

Guo Ye, et al.

Human Molecular Genetics, 27(3), 475-485 (2017)

Fragile X granules are a family of axonal ribonucleoprotein particles with circuit-dependent protein composition and mRNA cargos.

Eunice Chyung et al.

The Journal of comparative neurology, 526(1), 96-108 (2017-09-09)

Local axonal protein synthesis plays a crucial role in the formation and function of neuronal circuits. Understanding the role of this mechanism in specific circuits requires identifying the protein composition and mRNA cargos of the ribonucleoprotein particles (RNPs) that form

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Numéro d'article de commerce international

Référence	GTIN
F1554-200UL	04061837771491

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