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Monoclonal Anti-PTEN antibody produced in mouse

Name: Monoclonal Anti-PTEN antibody produced in mouse
Brand: SIGMA

~1 mg/mL, purified immunoglobulin, clone PTN-18, buffered aqueous solution

Synonym(s):

Anti-Mutated in multiple advanced cancers 1, Anti-PTEN1, Anti-PTENbeta, Anti-Phosphatase and tensin homolog, Anti-TEP1

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02097285

Conjugate:

unconjugated

Clone:

PTN-18, monoclonal

Application:

ARR, ELISA (i), ICC, WB

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Properties

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

PTN-18, monoclonal

form

buffered aqueous solution

mol wt

antigen ~55 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

immunocytochemistry: suitable using 4% paraformaldehyde-0.5% Triton X-100 fixation, indirect ELISA: suitable, microarray: suitable, western blot: 5-10 μg/mL using whole extract of rat brain

isotype

IgG2a

UniProt accession no.

P60484

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PTEN(5728)
mouse ... Pten(19211)
rat ... Pten(50557)

Description

General description

The PTEN (phosphatase and tensin homolog) gene is mapped to human chromosome 10q23. It shares sequence homology with protein tyrosine phosphatases and the cytoskeletal protein tensin.

Immunogen

synthetic peptide corresponding to the C-terminus of rat PTEN (amino acids 386-403).

Biochem/physiol Actions

The PTEN (phosphatase and tensin homolog) gene encodes a encodes a dual-specificity phosphatase that functions as a tumor suppressor by inhibiting phosphoinositide-3-kinase–protein kinase B/Akt (PI3K/PKB/Akt) signaling pathway, a crucial regulator of cell growth and survival and by negatively regulating the interactions of cell with the extracellular matrix. Mutations in this gene have been associated with several human cancers. Germline mutations in this gene have also been linked to Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), which are characterized by increased susceptibility to tumor formation and developmental defects.

The epitope recognized by the antibody resides within amino acids 386-403 of rat PTEN.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	WH0005728M1	SAB1404272	AMAB91736
Sigma-Aldrich P3487 Monoclonal Anti-PTEN antibody produced in mouse	Sigma-Aldrich WH0005728M1 Monoclonal Anti-PTEN antibody produced in mouse	Sigma-Aldrich SAB1404272 Monoclonal Anti-PTEN antibody produced in mouse	Sigma-Aldrich AMAB91736 Monoclonal Anti-PTEN antibody produced in mouse
species reactivity mouse, human, rat	species reactivity human	species reactivity human	species reactivity human
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... PTEN(5728) mouse ... Pten(19211) rat ... Pten(50557)	Gene Information human ... PTEN(5728)	Gene Information human ... PTEN(5728)	Gene Information human ... PTEN(5728)
clone PTN-18, monoclonal	clone 2G9, monoclonal	clone 3E7, monoclonal	clone CL11723, monoclonal
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Global Trade Item Number

SKU	GTIN
P3487-.2ML	04061838106834

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