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A1824

N-Acetyl-5-hydroxytryptamine

≥99% (HPLC), powder, antioxidant

Synonym(s):

N-Acetylserotonin, Normelatonin

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Size/SKUAvailabilityPrice
100 mg

Available to ship TODAYfromMILWAUKEE

$168.00

About This Item

Empirical Formula (Hill Notation):
C12H14N2O2
CAS Number:
1210-83-9
Molecular Weight:
218.25
NACRES:
NA.32
PubChem Substance ID:
24278209
UNSPSC Code:
12352209
EC Number:
214-916-5
MDL number:
MFCD00005656
Assay:
≥99% (HPLC)
Form:
powder

$168.00

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Product Name

N-Acetyl-5-hydroxytryptamine, ≥99% (HPLC), powder

Quality Segment

200

assay

≥99% (HPLC)

form

powder

color

white to faint yellow

mp

120-122 °C (lit.)

solubility

ethanol: 50 mg/mL

storage temp.

2-8°C

SMILES string

CC(=O)NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)

InChI key

MVAWJSIDNICKHF-UHFFFAOYSA-N

Gene Information

human ... MTNR1A(4543), MTNR1B(4544)

General description

N-Acetylserotonin (NAS)/normelatonin acts as a precursor of melatonin in the tryptophan metabolic pathway.

Application

N-Acetyl-5-hydroxytryptamine has been used to treat neuron cells and to analyze its effects on Krüppel-like factor 15 (KLF15) expression.

Biochem/physiol Actions

Immediate precursor of melatonin. It is formed from serotonin and acetyl-CoA in a reaction catalyzed by serotonin N-acetyl transferase, the rate-limiting enzyme in melatonin biosynthesis. This indoleamine is a weak agonist at melatonin receptors, and has moderate effects on G-protein stimulation and inhibition of cAMP accumulation.
N-acetyl-serotonin (NAS/normelatonin) can act as a shelter to neurons due to its protecting ability against oxidative challenges. It can also repress the actions of the transcription factor NF-kappaB. NAS possesses antioxidant and antiaging actions. It has protective action against β-amyloid induced neurotoxicity. It helps to maintain the optimal fluidity of the biological membranes.

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This Item
M1514A6251SML2058
N-Acetyl-5-hydroxytryptamine ≥99% (HPLC), powder

Sigma-Aldrich

A1824

N-Acetyl-5-hydroxytryptamine

Nω-Methyl-5-hydroxy­trypt­amine oxalate salt ≥90% (HPLC)

Sigma-Aldrich

M1514

Nω-Methyl-5-hydroxy­trypt­amine oxalate salt

N-Acetyl-DL-tryptophan

Sigma-Aldrich

A6251

N-Acetyl-DL-tryptophan

5,7-Dihydroxytryptamine hydrobromide ≥94% (HPLC)

Sigma-Aldrich

SML2058

5,7-Dihydroxytryptamine hydrobromide

description

≥99% (HPLC), powder

description

≥90% (HPLC)

description

-

description

≥94% (HPLC)

assay

≥99% (HPLC)

assay

≥90% (HPLC)

assay

≥98% (TLC)

assay

≥94% (HPLC)

form

powder

form

-

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

ethanol: 50 mg/mL

solubility

-

solubility

-

solubility

H2O: 2 mg/mL, clear

color

white to faint yellow

color

-

color

-

color

white to dark brown

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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