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A7232

AP-18

≥98% (HPLC), solid

Synonym(s):

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

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5 mg

Available to ship TODAYfromMILWAUKEE

$152.00
$129.20
25 mg

Available to ship TODAYfromMILWAUKEE

$458.00

About This Item

Empirical Formula (Hill Notation):
C11H12ClNO
CAS Number:
55224-94-7
Molecular Weight:
209.67
NACRES:
NA.77
PubChem Substance ID:
329770922
UNSPSC Code:
12352200
MDL number:
MFCD00102250
Assay:
≥98% (HPLC)
Form:
solid

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Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CC(=C/c1ccc(Cl)cc1)\C(C)=N\O

InChI

1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+

InChI key

MHTJEUOFLVQMCL-NJHPPEEMSA-N

Application

AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice

Biochem/physiol Actions

AP-18 is a selective TRPA1 channel blocker.
AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.

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This Item
SML0345SML1782O3139
AP-18 ≥98% (HPLC), solid

Sigma-Aldrich

A7232

AP-18

A 887826 ≥98% (HPLC)

Sigma-Aldrich

SML0345

A 887826

CATPB ≥98% (HPLC)

Sigma-Aldrich

SML1782

CATPB

Oxamflatin ≥98% (HPLC), solid

Sigma-Aldrich

O3139

Oxamflatin

form

solid

form

powder

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >10 mg/mL

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: soluble 13 mg/mL

color

white to off-white

color

white to beige

color

white to beige

color

-

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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