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Anti-Cdh1 antibody,Mouse monoclonal

Name: Anti-Cdh1 antibody,Mouse monoclonal
Brand: SIGMA
Price: 748 USD
Availability: InStock

clone DCS-266, purified from hybridoma cell culture

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0.1 mL	Available to ship TODAYfromMILWAUKEE	$748.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03457549

Conjugate:

unconjugated

Clone:

DCS-266, monoclonal

Application:

ARR, IP, WB

Citations:

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

DCS-266, monoclonal

form

buffered aqueous solution

mol wt

antigen 50 kDa

species reactivity

human

concentration

~2 mg/mL

technique(s)

immunoprecipitation (IP): suitable, microarray: suitable, western blot: 2-4 μg/mL using a HeLa cell nuclear extract

isotype

IgG1

UniProt accession no.

Q9UM11

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CDH1(999)

Description

General description

Cdh1 homophilic major cell adhesion molecule in epithelial cells belongs to cadherin superfamily.

Monoclonal Anti-Cdh1 (mouse IgG1 isotype) is derived from the DCS-266 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with a recombinant human cadherin-1 (Cdh1).

Immunogen

recombinant human Cdh1.

Application

Monoclonal Anti-Cdh1 antibody was used for immunoblotting of lysates in a study of Identification of Novel Human Cdt1-binding Proteins. It is suitable for western blotting with 2-4 μg/mL by using a HeLa cell nuclear extract. It is also suitable for immunoprecipitation and microarray.

Biochem/physiol Actions

Monoclonal Anti-Cdh1 reacts specifically with human Cdh1.

Monoclonal Anti-Cdh1 reacts specifically with human Cdh1. In eukaryotes, regulation of cell cycle progression depends on the expression of cyclins proteins. Degradation of mitotic cyclins follows ubiquitin-dependent pathways. The anaphase-promoting complex/cyclosome (APC/C) plays a vital role in progression. Initially at anaphase the APC/C requires the activator protein CDC20 to target securin and cyclin B1 for proteasome-dependent degradation, but later it require Cdh1 to maintain its active state till the next S phase. Another cyclin A/cdk2 mediated phosphorylation of Cdh1 may also prevents the activatory assembly of Cdh1 with APC, thus creating an environment permissive for accumulation of APC targets. It mediates Ca²⁺ dependent homophilic interactions, as the major adhesion receptor in adherens junctions.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4 containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	M7443	H4538	SAB1405091
Sigma-Aldrich C7855 Anti-Cdh1 antibody,Mouse monoclonal	Sigma-Aldrich M7443 Anti-MeCP2 antibody, Mouse monoclonal	Sigma-Aldrich H4538 Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal	Sigma-Aldrich SAB1405091 Monoclonal Anti-FZR1, (N-terminal) antibody produced in mouse
description clone DCS-266, purified from hybridoma cell culture	description clone Men-8, purified from hybridoma cell culture	description clone HDAC5-35, purified from hybridoma cell culture	description clone 3E12, purified immunoglobulin, buffered aqueous solution
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity human	species reactivity mouse, human, rat, monkey	species reactivity rat, mouse, human	species reactivity human
antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin
clone DCS-266, monoclonal	clone Men-8, monoclonal	clone HDAC5-35, monoclonal	clone 3E12, monoclonal
Gene Information human ... CDH1(999)	Gene Information human ... MECP2(4204) mouse ... Mecp2(17257) rat ... Mecp2(29386)	Gene Information human ... HDAC5(10014) mouse ... Hdac5(15184) rat ... Hdac5(84580)	Gene Information human ... FZR1(51343)

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