MTOX1097
MRP7 Knockout Caco-2 Cells
human male colorectal tissue (Source Disease: colon adenocarcinoma)
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| Size/SKU | Availability | Price |
|---|---|---|
1 vial | Available to ship TODAYfromSigmaAldrich Manufacturing LLC | $2,870.00 |
About This Item
Product Name
MRP7 Knockout Caco-2 Cells, one vial
biological source
human male colorectal tissue (Source Disease: colon adenocarcinoma )
Quality Segment
form
liquid
technique(s)
drug transporter assay: suitable, permeability assay: suitable
application(s)
ADME/TOX
storage temp.
−196°C
Gene Information
human ... ABCC10(89845)
General description
Application
Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases
Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes
Caco-2 Transporter Knockout Cell Based Assays
Features and Benefits
- A functional knockout of the MRP6 gene eliminates the reliance on chemical inhibitors to determine if a compound is an MRP6 substrate
- The vial format enables the MRP6 knockout cells to be included in standard drug transporter protocols
- Human assay with no interference from animal inhibitors
- Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality
Legal Information
1 of 1
This Item | |||
|---|---|---|---|
| description one vial | description one vial | description one vial | description one vial |
| biological source human male colorectal tissue (Source Disease: colon adenocarcinoma ) | biological source human male colorectal tissue (Source disease: adenocarcinoma) | biological source human male colorectal tissue (source disease: colon adenocarcinoma) | biological source human male colorectal tissue (Source disease: adenocarcinoma) |
| technique(s) drug transporter assay: suitable, permeability assay: suitable | technique(s) drug transporter assay: suitable, permeability assay: suitable | technique(s) permeability assay: suitable, drug transporter assay: suitable | technique(s) permeability assay: suitable, drug transporter assay: suitable |
| storage temp. −196°C | storage temp. −196°C | storage temp. −196°C | storage temp. −196°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| Gene Information human ... ABCC10(89845) | Gene Information human ... ABCG2(9429) | Gene Information human ... ABCC4(10257) | Gene Information human ... ABCC2(1244) |
| application(s) ADME/TOX | application(s) ADME/TOX | application(s) ADME/TOX | application(s) ADME/TOX |
Storage Class
12 - Non Combustible Liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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