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MTOX1105

MRP3 Knockout HepaRG™ Cells

human female liver (hepatocarcinoma and hepatitis C)

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1 vial

Estimated to ship onSeptember 21, 2026fromSigmaAldrich Manufacturing LLC

$1,420.00

About This Item

UNSPSC Code:
12352207
NACRES:
NA.81
Biological source:
human female liver (hepatocarcinoma and hepatitis C)

$1,420.00

Estimated to ship onSeptember 21, 2026Details

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Product Name

MRP3 Knockout HepaRG™ Cells, 1 vial

biological source

human female liver (hepatocarcinoma and hepatitis C)

Quality Segment

OMIM accession no.

storage temp.

−196°C

Gene Information

human ... MRP3(8714)

General description

HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG MRP3 knockout cells express the major xenobiotic sensors (PXR, CAR and AhR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.

Application

See technical bulletin for detailed protocols

Features and Benefits

HepaRG cells are the most metabolically active human hepatocyte cell line developed to date. These the cells are suitable for a wide variety of studies for drug metabolism, CYP induction, metabolism-mediated toxicity, transporter, and hepatotoxicity.

  • Sigma′s HepaRG MRP3 Knockout (KO) allows investigations of drug-transporter interactions involving MRP3 in the liver.
Zinc finger nucleases (ZFN) mediated Knock-out of ABCC3 (MRP3) gene.

  • The frame-shift mutation of ABCC3 gene was confirmed by fragment length analysis and DNA sequencing.
  • Loss of functionality was confirmed by loss of transport of selective substrates in sandwich culture assay.

Analysis Note

Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification, cytochrome oxidase I (COI) analysis for cell line species confirmation.

Legal Information

These products are covered by the License Agreement as described in Exhibit 1 and 2, in the technical bulletin.
HepaRG is a trademark of BioPredic International company

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

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description

1 vial

description

one vial

description

1 vial

description

one vial

biological source

human female liver (hepatocarcinoma and hepatitis C)

biological source

human female liver (hepatocarcinoma and hepatitis C tumor)

biological source

human female liver (Source Disease: Hepatocarcinoma and Hepatitis C)

biological source

human female liver (hepatocarcinoma and hepatitis C tumor)

storage temp.

−196°C

storage temp.

−196°C

storage temp.

−196°C

storage temp.

−196°C

OMIM accession no.

604323

OMIM accession no.

601107

OMIM accession no.

-

OMIM accession no.

604032

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Gene Information

human ... MRP3(8714)

Gene Information

human ... ABCC2(1244)

Gene Information

human ... ABCB1(1346307)

Gene Information

human ... EIF2AK3(9451)

Storage Class

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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