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Anti-Pro-BDNF antibody produced in rabbit

Name: Anti-Pro-BDNF antibody produced in rabbit
Brand: SIGMA
Price: 1240 CAD

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-pro-Brain-derived Neurotrophic Factor

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Size/SKU	Availability	Price
200 μL	Please contact Customer Service for Availability	$1,240.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD08705507

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$1,240.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, human, rat

technique(s)

western blot: 1:200 using rat glioma C6 and human neuroblastoma SH-SY5Y cell lines, western blot: 1:400 using recombinant mouse proBDNF

UniProt accession no.

P23560

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BDNF(627)
mouse ... Bdnf(12064)
rat ... Bdnf(24225)

Description

General description

Does not cross react with pro-NGF, pro-NT-3, or mature BDNF.

The brain derived neurotrophic factor (BDNF) gene is mapped to human chromosome 11p14.1. The gene encodes a precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. Does not cross react with pro-NGF, pro-NT-3, or mature BDNF.

Immunogen

peptide corresponding to amino acid residues 72-88 of human BDNF (precursor). This sequence has 16/17 residues identical in mouse and rat.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins. Neurotrophins are synthesized as preproneurotrophin precursors and further processed to proneurotrophins and subsequently to neurotrophins. BDNF is expressed in the developing and the mature brain. The influence of BDNF is mediated by its binding to TrkB receptor and sometimes the receptor p75^NTR. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin and ≤0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200744	SAB5700726	SAB1402127
Sigma-Aldrich P1374 Anti-Pro-BDNF antibody produced in rabbit	Sigma-Aldrich SAB4200744 Anti-BDNF antibody, Mouse Monoclonal	Sigma-Aldrich SAB5700726 Anti-BDNF antibody produced in rabbit	Sigma-Aldrich SAB1402127 Monoclonal Anti-BDNF antibody produced in mouse
description affinity isolated antibody, lyophilized powder	description clone BDNF129-13, purified from hybridoma cell culture	description -	description clone 1B10, purified immunoglobulin, buffered aqueous solution
antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture	antibody form affinity isolated antibody	antibody form purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source mouse	biological source rabbit	biological source mouse
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
clone polyclonal	clone BDNF129-13, monoclonal	clone polyclonal	clone 1B10, monoclonal
form lyophilized powder	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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