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S166

Saclofen

solid

Synonym(s):

β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$349.00

About This Item

Empirical Formula (Hill Notation):
C9H12ClNO3S
CAS Number:
125464-42-8
Molecular Weight:
249.71
NACRES:
NA.32
PubChem Substance ID:
329824485
UNSPSC Code:
51111800
MDL number:
MFCD00216817
Form:
solid
Quality level:
200

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form

solid

Quality Level

200

color

white

solubility

0.1 M NaOH: 20 mg/mL

SMILES string

NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

InChI key

JYLNVJYYQQXNEK-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)

Application

Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.[1]
Saclofen has been used as a GABAB receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.

Biochem/physiol Actions

Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.[2]
Saclofen is the sulphonic analog of baclofen and is a selective GABAB receptor antagonist.

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This Item
1048200B0200000A6566
Saclofen solid

Sigma-Aldrich

S166

Saclofen

Baclofen United States Pharmacopeia (USP) Reference Standard

USP

1048200

Baclofen

Baclofen European Pharmacopoeia (EP) Reference Standard

B0200000

Baclofen

2-Hydroxysaclofen ≥98% (TLC), solid

Sigma-Aldrich

A6566

2-Hydroxysaclofen

form

solid

form

-

form

-

form

solid

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

200

solubility

0.1 M NaOH: 20 mg/mL

solubility

-

solubility

-

solubility

H2O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL

color

white

color

-

color

-

color

white

Gene Information

human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000544335
0000544335
0000510273
0000510273
0000500585

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Eisuke Koya et al.
Neuropharmacology, 56 Suppl 1, 177-185 (2008-06-21)
Cue-induced drug-seeking in rodents progressively increases after withdrawal from cocaine, suggesting that cue-induced cocaine craving incubates over time. Here, we explored the role of the medial prefrontal cortex (mPFC, a brain area previously implicated in cue-induced cocaine seeking) in this
Molecular Mechanisms Underlying the Enhanced Analgesic Effect of Oxycodone Compared to Morphine in Chemotherapy-Induced Neuropathic Pain
Karine T
PLoS ONE (2014)
David P Archer et al.
Anesthesia and analgesia, 104(4), 840-846 (2007-03-23)
Synaptic plasticity is thought to provide a molecular mechanism for learning and memory. N-methyl-d-aspartate receptor-mediated plasticity requires that N-methyl-d-aspartate receptor activation coincides with postsynaptic depolarizing potentials (DPSP(A)'s). Pentobarbital, in high concentrations, enhances DPSP(A)'s, but high concentrations suppress synaptic plasticity, probably
View All Related Papers

Global Trade Item Number

SKUGTIN
SAB5701894-100UL04065267678719
SAB5700317-100UL04065265172622
SAB5701958-100UL04065267679358
S166-5MG04061836912925

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