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Anti-SMN antibody, Mouse monoclonal

Name: Anti-SMN antibody, Mouse monoclonal
Brand: SIGMA
Price: 692.75 USD
Availability: InStock

clone 2B1, purified from hybridoma cell culture

Synonym(s):

Anti-Survival of Motor Neurons

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$815.00 $692.75

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01634191

Conjugate:

unconjugated

Clone:

2B1, monoclonal

Application:

ARR, WB

Citations:

$692.75

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

2B1, monoclonal

form

buffered aqueous solution

species reactivity

Xenopus, human, mouse

concentration

~2 mg/mL

technique(s)

microarray: suitable, western blot: 2-4 μg/mL using A431 cell extract

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SMN1(6606), SMN2(6607)
mouse ... Smn1(20595)

Description

General description

Mouse monoclonal clone 2B1 anti-SMN antibody recognizes human, mouse, and Xenopus survival of motor neurons proteins.

Immunogen

recombinant human SMN

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Enzyme-linked immunosorbent assay (1 paper)

Mouse monoclonal clone 2B1 anti-SMN antibody is an important tool for studying the role of the survival of motor neurons protein in nuclear processes and spinal muscular atrophy (SMA). It may be used in immunoblotting (~35 kDa), immunoprecipitation, and immunocytochemistry.

Biochem/physiol Actions

Survival of Motor Neurons (SMN) complex is important in various biological processes, such as assembly and restructuring of spliceosomal small nuclear ribonucleoproteins (snRNPs), pre mRNA splicing and transcription. Spinal muscular atrophy (SMA) is caused by reduced expression or mutations in the survival of motor neurons (SMN) protein. Deletion or mutation in the telomeric copy (SMN1) causes the SMA phenotype. The severity of SMA is in direct correlation with the expression level of the SMN protein, either from the SMN1 gene or a different spliced form of SMN from the SMN2 gene. The SMN complex interacts with various protein substrates such as Sm and Lsm proteins of the spliceosomal snRNPs, fibrillarin, GAR1, RNA helicase A, the human hnRNP proteins (hnRNPQ, U and R), coilin and p53.

The antibody recognizes human, mouse, and Xenopus SMN.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15mM sodium azide.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in "frostfree" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	M2320	M0691	A1106
Sigma-Aldrich S2944 Anti-SMN antibody, Mouse monoclonal	Sigma-Aldrich M2320 Anti-MAP2 (2a+2b) antibody, Mouse monoclonal	Sigma-Aldrich M0691 Anti-Myosin VI antibody, Mouse monoclonal	Sigma-Aldrich A1106 Anti-ATM antibody,Mouse monoclonal
description clone 2B1, purified from hybridoma cell culture	description ~2 mg/mL, clone AP-20, purified from hybridoma cell culture	description ~1 mg/mL, clone MUD-19, purified from hybridoma cell culture	description clone MAT3-4G10/8, purified from hybridoma cell culture
Gene Information human ... SMN1(6606), SMN2(6607) mouse ... Smn1(20595)	Gene Information human ... MAP2(4133) mouse ... Mtap2(17756) rat ... Map2(25595)	Gene Information human ... MYO6(4646) mouse ... Myo6(17920) rat ... Myo6(315840)	Gene Information human ... ATM(472) mouse ... Atm(11920)
species reactivity Xenopus, human, mouse	species reactivity Xenopus, mouse, quail, human, bovine, rat, aquatic salamander	species reactivity human, mouse, rat	species reactivity human, mouse
antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone 2B1, monoclonal	clone AP-20, monoclonal	clone MUD-19, monoclonal	clone MAT3-4G10/8, monoclonal
biological source mouse	biological source mouse	biological source mouse	biological source mouse

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